1071000-98-0

1071000-98-0 structure

Name: 1,1,1,2,2-Pentafluoro-7-phenyl-3-heptanone
Chemical Name: 1,1,1,2,2-pentafluoro-7-phenylheptan-3-one
CAS Number: 1071000-98-0
Molecular Formula: C₁₃H₁₃F₅O
Molecular Weight: 280.234
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2016-06-26 15:31:20
Modify Date: 2024-01-08 11:17:11
FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis[1][2].

Name	1,1,1,2,2-pentafluoro-7-phenylheptan-3-one
Synonyms	1,1,1,2,2-Pentafluoro-7-phenyl-3-heptanone 3-Heptanone, 1,1,1,2,2-pentafluoro-7-phenyl- Phospholipase A FKGK 11

Description	FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	PLA2
In Vitro	FKGK11 shows 99.4 ± 0.1% inhibition of GVIA iPLA2 and only 28 ± 1% for GV sPLA2 at 0.091 mole fraction[1]. FKGK11 reduces adhesion, migration, and invasion of EOC (epithelial ovarian cancer) cells[2].
In Vivo	FKGK11 inhibits tumor development in the xenograft mouse model[2]. FKGK11 shows a significant increase in the number of macrophages and degenerating fibres with disrupted myelin sheaths in cPLA2 GIVA−/− mice and C57BL/6 mice[3].
References	[1]. Kokotos G, et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. [2]. Yan Xu, et al. Abstract 3525: Targeting Group VIA phospholipase A2 using small molecules for ovarian cancer treatment. Cancer Res (2011) 71 (8_Supplement): 3525. [3]. López-Vales R, et al. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Oct;131(Pt 10):2620-31.

RIDADR	NONH for all modes of transport