1,1,1,2,2-Pentafluoro-7-phenyl-3-heptanone

Modify Date: 2024-01-08 11:17:11

1,1,1,2,2-Pentafluoro-7-phenyl-3-heptanone structure	Common Name	1,1,1,2,2-Pentafluoro-7-phenyl-3-heptanone
	CAS Number	1071000-98-0	Molecular Weight	280.234
	Density	1.2±0.1 g/cm3	Boiling Point	288.9±40.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₃F₅O	Melting Point	N/A
	MSDS	USA	Flash Point	110.7±21.5 °C

Use of 1,1,1,2,2-Pentafluoro-7-phenyl-3-heptanone

FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis[1][2].

Name	1,1,1,2,2-pentafluoro-7-phenylheptan-3-one
Synonym	More Synonyms

Description	FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	PLA2
In Vitro	FKGK11 shows 99.4 ± 0.1% inhibition of GVIA iPLA2 and only 28 ± 1% for GV sPLA2 at 0.091 mole fraction[1]. FKGK11 reduces adhesion, migration, and invasion of EOC (epithelial ovarian cancer) cells[2].
In Vivo	FKGK11 inhibits tumor development in the xenograft mouse model[2]. FKGK11 shows a significant increase in the number of macrophages and degenerating fibres with disrupted myelin sheaths in cPLA2 GIVA−/− mice and C57BL/6 mice[3].
References	[1]. Kokotos G, et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. [2]. Yan Xu, et al. Abstract 3525: Targeting Group VIA phospholipase A2 using small molecules for ovarian cancer treatment. Cancer Res (2011) 71 (8_Supplement): 3525. [3]. López-Vales R, et al. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Oct;131(Pt 10):2620-31.

Density	1.2±0.1 g/cm3
Boiling Point	288.9±40.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₃F₅O
Molecular Weight	280.234
Flash Point	110.7±21.5 °C
Exact Mass	280.088654
PSA	17.07000
LogP	5.40
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.434

MSDS(Chinese)

RIDADR	NONH for all modes of transport

1,1,1,2,2-Pentafluoro-7-phenyl-3-heptanone

3-Heptanone, 1,1,1,2,2-pentafluoro-7-phenyl-

Phospholipase A

FKGK 11

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: FKGK 11
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: FKGK11
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: FKGK11
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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