82058-16-0
82058-16-0 structure
- Name: NSC 33994
- Chemical Name: 2-(diethylaminomethyl)-4-[(E)-4-[3-(diethylaminomethyl)-4-hydroxyphenyl]hex-3-en-3-yl]phenol
- CAS Number: 82058-16-0
- Molecular Formula: C28H42N2O2
- Molecular Weight: 438.64500
- Catalog: Signaling Pathways Epigenetics JAK
- Create Date: 2016-05-22 18:14:54
- Modify Date: 2024-01-09 16:16:49
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NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1].
| Name | 2-(diethylaminomethyl)-4-[(E)-4-[3-(diethylaminomethyl)-4-hydroxyphenyl]hex-3-en-3-yl]phenol |
|---|---|
| Synonyms |
4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]phenol
(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol 4,4 inverted exclamation marka-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol} |
| Description | NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
JAK2:60 nM (IC50, JAK2 Val617Phe kinase activity ) |
| In Vitro | NSC 33994 (G6) reduces the levels of phospho-JAK2 in both a dose- and time-dependent manner[1]. NSC 33994 (G6, 0-25 μM, 0-48 h) inhibits phospho-JAK2 (pY1007/pY1008) in a dose-dependent and time-dependent manner[1]. |
| References |
| Molecular Formula | C28H42N2O2 |
|---|---|
| Molecular Weight | 438.64500 |
| Exact Mass | 438.32500 |
| PSA | 46.94000 |
| LogP | 6.51220 |
| RIDADR | NONH for all modes of transport |
|---|
