NSC 33994
NSC 33994 structure
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Common Name | NSC 33994 | ||
|---|---|---|---|---|
| CAS Number | 82058-16-0 | Molecular Weight | 438.64500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H42N2O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of NSC 33994NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1]. |
| Name | 2-(diethylaminomethyl)-4-[(E)-4-[3-(diethylaminomethyl)-4-hydroxyphenyl]hex-3-en-3-yl]phenol |
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| Synonym | More Synonyms |
| Description | NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1]. |
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| Related Catalog | |
| Target |
JAK2:60 nM (IC50, JAK2 Val617Phe kinase activity ) |
| In Vitro | NSC 33994 (G6) reduces the levels of phospho-JAK2 in both a dose- and time-dependent manner[1]. NSC 33994 (G6, 0-25 μM, 0-48 h) inhibits phospho-JAK2 (pY1007/pY1008) in a dose-dependent and time-dependent manner[1]. |
| References |
| Molecular Formula | C28H42N2O2 |
|---|---|
| Molecular Weight | 438.64500 |
| Exact Mass | 438.32500 |
| PSA | 46.94000 |
| LogP | 6.51220 |
| RIDADR | NONH for all modes of transport |
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~%
NSC 33994 CAS#:82058-16-0 |
| Literature: Burckhalter et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 1894,1896 |
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PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.
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RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer.
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Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.
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| 4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]phenol |
| (E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol |
| 4,4 inverted exclamation marka-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol} |