210297-47-5

210297-47-5 structure

Name: HA-100 hydrochloride
Chemical Name: 5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride
CAS Number: 210297-47-5
Molecular Formula: C₁₃H₁₇Cl₂N₃O₂S
Molecular Weight: 350.26
Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
Create Date: 2017-07-27 18:30:17
Modify Date: 2024-01-02 23:44:48
HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor[1][2].

Name	5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride
Synonyms	Isoquinoline, 5-(1-piperazinylsulfonyl)-, hydrochloride (1:2) 5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride

Description	HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Myosin Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	PKA:8 μM (IC50) PKC:12 μM (IC50) PKC:6.5 μM (Ki) PKG:4 μM (IC50) MLCK:240 μM (IC50) MLCK:61 μM (Ki)
References	[1]. Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. [2]. Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557.