127828-22-2
127828-22-2 structure
- Name: Amino-PEG2-NH-Boc
- Chemical Name: tert-butyl N-[2-(2-aminoethoxy)ethyl]carbamate
- CAS Number: 127828-22-2
- Molecular Formula: C9H20N2O3
- Molecular Weight: 204.26700
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2016-09-16 11:35:22
- Modify Date: 2024-01-10 09:58:52
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Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
| Name | tert-butyl N-[2-(2-aminoethoxy)ethyl]carbamate |
|---|---|
| Synonyms |
AmbotzPEG1067
1-t-butoxycarbonylamino-3-oxa-pentan-5-amine N-Boc-2-(2-amino-ethoxy)-ethylamine tert-butyl 2-(2-aminoethoxy)ethylcarbamate N-(tert-butyloxycarbonyl)-2,2'-oxybis(ethylamine) 5-(tert-butyloxycarbonylamino)-3-oxa-pentyl amine N-t-butoxycarbonyl-3-oxa-1,5-pentanediamine tert-Butyl [2-(2-aminoethoxy)ethyl]carbamate BOCNH-PEG1-CH2CH2NH2 |
| Description | Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
| Density | 1.024g/cm3 |
|---|---|
| Boiling Point | 321.128ºC at 760 mmHg |
| Molecular Formula | C9H20N2O3 |
| Molecular Weight | 204.26700 |
| Flash Point | 148.013ºC |
| Exact Mass | 204.14700 |
| PSA | 77.07000 |
| LogP | 1.39110 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.457 |
| Water Solubility | Soluble (53 g/L) (25 ºC) |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2924199090 |
|
~79%
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| Literature: EP1745802 A1, ; Page/Page column 17 ; |
|
~82%
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| Literature: Journal of Organic Chemistry, , vol. 72, # 7 p. 2289 - 2296 |
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~99%
127828-22-2 |
| Literature: Tetrahedron Letters, , vol. 47, # 17 p. 2915 - 2919 |
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~%
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| Literature: EP2123283 A1, ; Page/Page column 15 ; |
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| Literature: US2011/269965 A1, ; |
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| Literature: US2011/269965 A1, ; |
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| Literature: US2011/269965 A1, ; |
| Precursor 6 | |
|---|---|
| DownStream 0 | |
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |