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23205-42-7

23205-42-7 structure
23205-42-7 structure
  • Name: 3-Deazauridine
  • Chemical Name: 3-Deazauridine
  • CAS Number: 23205-42-7
  • Molecular Formula: C10H13NO6
  • Molecular Weight: 243.21
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
  • Create Date: 2018-11-20 19:36:34
  • Modify Date: 2024-01-12 17:34:55
  • 3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1].

Name 3-Deazauridine
Synonyms 3-deazauridine
EINECS 245-488-8
MFCD00006522
Description 3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1].
Related Catalog
Target

Cytidine triphosphate synthase[1]

In Vitro 3-Deazauridine (DAUR) 对 L1210 白血病细胞具有优异的抗肿瘤活性[1]。
In Vivo 3-Deazauridine (DAUR) (250 mg/kg/天;腹腔注射;1-9 天) 对小鼠中的 L1210 白血病细胞显示出中等活性[1]。 3-Deazauridine (腹腔注射;给药 5 次) 对比格犬和恒河猴的致死剂量分别为 250 mg/kg/day 和 417 mg/kg/day,最低毒性剂量为 62.5 mg/kg/day 和 104 mg/kg/day,无毒剂量分别为 31.25 mg/kg/day 和 52 mg/kg/day[1]。
References

[1]. Moriconi WJ, et al. 3-Deazauridine (NSC 126849): an interesting modulator of biochemical response. Invest New Drugs. 1986;4(1):67-84.  

Density 1.718g/cm3
Boiling Point 528ºC at 760mmHg
Melting Point 233-235ºC
Molecular Formula C10H13NO6
Molecular Weight 243.21
Flash Point 273.1ºC
Exact Mass 243.07400
PSA 112.15000
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.706

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1148000
CHEMICAL NAME :
2(1H)-Pyridone, 4-hydroxy-1-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
23205-42-7
LAST UPDATED :
199206
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H13-N-O6
MOLECULAR WEIGHT :
243.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
1 nmol
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,295,1983
RTECS UV1148000
Precursor  3

DownStream  0