Name | 3-Deazauridine |
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Synonyms |
3-deazauridine
EINECS 245-488-8 MFCD00006522 |
Description | 3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1]. |
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Related Catalog | |
Target |
Cytidine triphosphate synthase[1] |
In Vitro | 3-Deazauridine (DAUR) 对 L1210 白血病细胞具有优异的抗肿瘤活性[1]。 |
In Vivo | 3-Deazauridine (DAUR) (250 mg/kg/天;腹腔注射;1-9 天) 对小鼠中的 L1210 白血病细胞显示出中等活性[1]。 3-Deazauridine (腹腔注射;给药 5 次) 对比格犬和恒河猴的致死剂量分别为 250 mg/kg/day 和 417 mg/kg/day,最低毒性剂量为 62.5 mg/kg/day 和 104 mg/kg/day,无毒剂量分别为 31.25 mg/kg/day 和 52 mg/kg/day[1]。 |
References |
Density | 1.718g/cm3 |
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Boiling Point | 528ºC at 760mmHg |
Melting Point | 233-235ºC |
Molecular Formula | C10H13NO6 |
Molecular Weight | 243.21 |
Flash Point | 273.1ºC |
Exact Mass | 243.07400 |
PSA | 112.15000 |
Vapour Pressure | 0mmHg at 25°C |
Index of Refraction | 1.706 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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RTECS | UV1148000 |
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~% 23205-42-7 |
Literature: Journal of Organic Chemistry, , vol. 72, # 1 p. 173 - 179 |
~% 23205-42-7 |
Literature: Journal of Organic Chemistry, , vol. 72, # 1 p. 173 - 179 |
~% 23205-42-7 |
Literature: Journal of Organic Chemistry, , vol. 72, # 1 p. 173 - 179 |
Precursor 3 | |
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DownStream 0 |