- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: m-PEG10-alcohol
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: m-PEG10-alcohol
- Price: ￥2108.0/100mg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: m-PEG10-alcohol
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Decaethylene glycol monomethyl ether
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
27425-92-9
27425-92-9 structure
- Name: m-PEG10-alcohol
- Chemical Name: 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
- CAS Number: 27425-92-9
- Molecular Formula: C21H44O11
- Molecular Weight: 472.568
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2018-03-19 08:00:00
- Modify Date: 2024-01-05 10:51:26
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m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol |
|---|---|
| Synonyms |
O-methyl-decaethylene glycol
O-Methyl-decaaethylenglykol 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-ol Decaethylene Glycol Monomethyl Ether |
| Description | m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
[1]. Nnochiri Ekwuribe, et al. Calcitonin drug-oligomer conjugates, and uses thereof. US20040091452A1. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 524.3±45.0 °C at 760 mmHg |
| Melting Point | 19ºC |
| Molecular Formula | C21H44O11 |
| Molecular Weight | 472.568 |
| Flash Point | 270.9±28.7 °C |
| Exact Mass | 472.288361 |
| PSA | 112.53000 |
| LogP | -4.02 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.455 |
| HS Code | 2909499000 |
|---|
|
~45%
27425-92-9 |
| Literature: US6355646 B1, ; Page column 12 ; |
|
~%
27425-92-9 |
| Literature: US2003/228652 A1, ; |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| HS Code | 2909499000 |
|---|---|
| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |