Name | 3-chloro-N-phenylaniline |
---|---|
Synonyms |
Benzenamine, 3-chloro-N-phenyl-
(3-Chlor-phenyl)-phenyl-amin EINECS 202-922-0 3-chloro-N-phenyl-aniline 3-Chloro-N-phenyl-benzenamine N-(3-Chlorophenyl)aniline MFCD00000590 N-(m-Chlorophenyl)aniline (3-chlorophenyl)phenylamine (3-Cl-C6H4)PhNH m-Chlorodiphenylamine 3-Chloro-N-phenylaniline 3-Chlorodiphenylamine Benzenamine,3-chloro-N-phenyl N-(3-chlorophenyl)-N-phenylamine |
Description | 3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research[1]. |
---|---|
Related Catalog | |
Target |
Kd: 6 µM (N-domain of cardiac troponin C (cTnC)) Kd: 10 µM (cNTnC–cSp chimera)[1] |
In Vitro | 3-Chlorodiphenylamine is able to bind highly (Kd=10 µM) to a chimeric protein consisting of the regulatory N-domain of cTnC (cNTnC) and the switch region of cTnI (cNTnC–cSp chimera)[1]. 3-Chlorodiphenylamine (100 µM) results in a 1.5-fold increase in the Ca2+ sensitivity of force development without altering the maximal or resting forces in skinned ventricular trabeculae[1]. 3-Chlorodiphenylamine (25-100 µM) increases Ca2+ sensitivity of the N-domain of intact cTnC after reconstitution into the cTn complex (cTnC complexed with cTnI and cTnT) in a concentration-dependent manner. It exhibits pCa50s with 6.39±0.01, 6.65±0.01, and 6.73±0.02 in the presence of 25, 50, and 100 µM 3-Chlorodiphenylamine, respectively[1]. |
References |
Density | 1.2±0.1 g/cm3 |
---|---|
Boiling Point | 337.8±0.0 °C at 760 mmHg |
Melting Point | 112 °C |
Molecular Formula | C12H10ClN |
Molecular Weight | 203.667 |
Flash Point | 147.4±23.2 °C |
Exact Mass | 203.050171 |
PSA | 12.03000 |
LogP | 3.86 |
Vapour Pressure | 0.0±0.7 mmHg at 25°C |
Index of Refraction | 1.643 |
Hazard Codes | Xn |
---|---|
Risk Phrases | R20/21/22 |
Safety Phrases | S28-S36/37 |
HS Code | 2921440000 |
Precursor 9 | |
---|---|
DownStream 10 | |
HS Code | 2921440000 |
---|---|
Summary | 2921440000. diphenylamine and its derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0% |