Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CYCLOARTENOL
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

BioBioPha
China
Product Name: CYCLOARTENOL
Price: ￥3400.0/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: CYCLOARTENOL
Price: ￥4488.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 9,19-Cyclolanost-24-en-3-ol, (3beta)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

469-38-5

469-38-5 structure

Name: CYCLOARTENOL
Chemical Name: cycloartenol
CAS Number: 469-38-5
Molecular Formula: C₃₀H₅₀O
Molecular Weight: 426.71700
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-08-19 10:34:16
Modify Date: 2024-01-02 17:00:19
Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2].

Name	cycloartenol
Synonyms	CYCLOARTENOL 9,19-Cyclolanost-24-en-3-ol 9,19-CYCLO-9BETA-LANOST-24-EN-3BETA-OL

Description	Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
In Vitro	Cycloartenol inhibits the proliferation and the colony formation potential of the glioma U87 cells in a concentration-dependent manner. The antiproliferative effects are found to be due to induction of Sub-G1 cell cycle arrest and triggering of apoptosis. Cycloartenol also causes significant alteration in the expression of Bax and Bcl-2[2].
References	[1]. Niu H, et al. Cycloartenol exerts anti-proliferative effects on Glioma U87 cells via induction of cell cycle arrest and p38 MAPK-mediated apoptosis. J BUON. 2018 Nov-Dec;23(6):1840-1845. [2]. Zhang ZL, et al. [Research advance of functional plant pharmaceutical cycloartenol about pharmacological and physiological activity]. Zhongguo Zhong Yao Za Zhi. 2017 Feb;42(3):433-437.

Density	1.01 g/cm3
Boiling Point	505.5ºC at 760 mmHg
Melting Point	115-117ºC
Molecular Formula	C₃₀H₅₀O
Molecular Weight	426.71700
Flash Point	221.9ºC
Exact Mass	426.38600
PSA	20.23000
LogP	8.16890
Vapour Pressure	2.47E-12mmHg at 25°C
Index of Refraction	1.538

Hazard Codes	Xi: Irritant;
Safety Phrases	22-24/25

67-56-1

21238-33-5

1449-09-8

469-38-5

Literature: MORINAGA MILK INDUSTRY CO., LTD. Patent: EP1882472 A1, 2008 ; Location in patent: Page/Page column 14 ;

21238-33-5

~93%

469-38-5

Literature: Yoshida, Kumi; Hirose, Yoshihiko; Imai, Yutaka; Kondo, Tadao Agricultural and Biological Chemistry, 1989 , vol. 53, # 7 p. 1901 - 1912

14050-42-1

514-45-4

469-38-5

79-63-0

Literature: Hart, Elizabeth A.; Hua, Ling; Darr, Lisa B.; Wilson, William K.; Pang, Jihai; Matsuda, Seiichi P. T. Journal of the American Chemical Society, 1999 , vol. 121, # 42 p. 9887 - 9888

54910-48-4

514-45-4

469-38-5

79-63-0

Literature: Lodeiro, Silvia; Schulz-Gasch, Tanja; Matsuda, Seiichi P. T. Journal of the American Chemical Society, 2005 , vol. 127, # 41 p. 14132 - 14133

1259-10-5

469-38-5

Literature: Seo, Shujiro; Uomori, Atsuko; Yoshimura, Yohko; Takeda, Ken'ichi; Seto, Haruo; et.al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2407 - 2414

14050-42-1

469-38-5

Literature: Matsuda; Darr; Hart; Herrera; McCann; Meyer; Pang; Schepmann Organic letters, 2000 , vol. 2, # 15 p. 2261 - 2263

136891-87-7

469-38-5

Literature: Majumder; Ghosal Journal of the Indian Chemical Society, 1991 , vol. 68, # 2 p. 88 - 91

Precursor 5
67-56-1 21238-33-5 14050-42-1 1259-10-5
136891-87-7
DownStream 6
21238-33-5 514-45-4 79-63-0 110654-88-1
23515-91-5 35012-08-9

469-38-5	85955-30-2
1768-79-2	21238-33-5
4657-58-3	1259-10-5
84605-18-5