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9012-76-4

9012-76-4 structure
9012-76-4 structure
  • Name: Chitosan
  • Chemical Name: chitosan
  • CAS Number: 9012-76-4
  • Molecular Formula: (C6H13NO5)n
  • Molecular Weight: 161.16 (monomer)
  • Catalog: Biochemical Carbohydrate Polysaccharide
  • Create Date: 2018-02-07 08:00:00
  • Modify Date: 2024-01-02 18:29:21
  • Chitosan is a natural polycationic linear polysaccharide derived from chitin.
Name chitosan
Synonyms EINECS 222-311-2
Poly(beta-(1,4)-D-glucosamine)
Poly(beta-(1,4)-2-amino-2-deoxy-D-glucose)
MFCD00161512
Chitosan
Description Chitosan is a natural polycationic linear polysaccharide derived from chitin.
Related Catalog
In Vitro Chitosans are recognized as versatile biomaterials because of their non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan is reported to have other biological properties, such as antitumor, antimicrobial, and antioxidant activities. It can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity treatment and as a scaffold for tissue engineering[1]. Antimicrobial activity of chitosan has been demonstrated against many bacteria, filamentous fungi and yeasts. Chitosan has wide spectrum of activity and high killing rate against Gram-positive and Gram-negative bacteria, but lower toxicity toward mammalian cells[2]. Chitosan exhibits antitumor activity against different types of cancer. For example, chitosan decreases adhesion of primary melanoma A375 cell line and decreases proliferation of primary melanoma SKMEL28 cell line, it has potent pro-apoptotic effects against RPMI7951, a metastatic melanoma cell line[3]. Chitosan and its derivatives act as antioxidants by scavenging oxygen radicals such as hydroxyl, superoxide, alkyl as well as highly stable DPPH radicals in vitro[4].
In Vivo Chitosan treatment dramatically increases lifespan and inhibits tumor metastasis especially in treatment groups of the low-molecular weight compound[5]. Chitosan has some apparent treatment effects on rat PCP by reducing HSP70 mRNA expression and lung inflammation, increasing the concentrations of IL-10 and IFN-γ as well as CD4(+) T-lymphocyte numbers, reducing the CD8(+) T-lymphocyte numbers and the concentration of TNF-α and inducing significant ultrastructural damage to P. carinii[6].
References

[1]. Cheung RC, et al. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015 Aug 14;13(8):5156-86.

[2]. Kong M, et al. Antimicrobial properties of chitosan and mode of action: a state of the art review. Int J Food Microbiol. 2010 Nov 15;144(1):51-63.

[3]. Gibot L, et al. Anticancer properties of chitosan on human melanoma are cell line dependent.Int J Biol Macromol. 2015 Jan;72:370-9.

[4]. Younes I, et al. Chitin and chitosan preparation from marine sources. Structure, properties and applications. Mar Drugs. 2015 Mar 2;13(3):1133-74.

[5]. Yeh MY, et al. Effects of chitosan on xenograft models of melanoma in C57BL/6 mice and hepatoma formation in SCID mice. Anticancer Res. 2013 Nov;33(11):4867-73.

[6]. Liu AB, et al. Therapeutic efficacies of chitosan against Pneumocystis pneumonia of immunosuppressed rat. Parasite Immunol. 2014 Jul;36(7):292-302
Density 1.75g/cm3
Melting Point 88ºC
Molecular Formula (C6H13NO5)n
Molecular Weight 161.16 (monomer)
Index of Refraction 1.7
Storage condition room temp
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility dilute aqueous acid (pH <6.5).: soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FM6300000
CHEMICAL NAME :
Chitosan
CAS REGISTRY NUMBER :
9012-76-4
LAST UPDATED :
199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
957 gm/kg/58D-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 15,555,1976
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Phrases 20/21/22-36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany -
RTECS FM6300000
HS Code 2932999099
Precursor  1

DownStream  1

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Chemsrc provides CAS#:9012-76-4 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 9012-76-4 | Chemsrc address: https://www.chemsrc.com/en/baike/599526.html

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