1383478-94-1
1383478-94-1 structure
- Name: CYM 9484
- Chemical Name: N-[4-(Dimethylsulfamoyl)phenyl]-4-[hydroxy(diphenyl)methyl]-1-pip eridinecarbothioamide
- CAS Number: 1383478-94-1
- Molecular Formula: C27H31N3O3S2
- Molecular Weight: 509.68300
- Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
- Create Date: 2017-10-29 03:21:29
- Modify Date: 2024-01-10 07:29:55
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CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM[1].
| Name | N-[4-(Dimethylsulfamoyl)phenyl]-4-[hydroxy(diphenyl)methyl]-1-pip eridinecarbothioamide |
|---|
| Description | CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
NPYY2 receptor:19 nM (IC50) |
| In Vitro | SF-11 is a selective, brain-penetrant NPY Y2 receptor antagonist with an IC50 value of 190 nM. Systematically explore the SAR of the hit molecule SF-11 that leads to the identification of selective and highly potent small molecule NPY Y2 receptor antagonist CYM 9484 (Compound 16). CYM 9484 is 10-fold more potent than the hit molecule SF-11. CYM 9484 is prepared by the coupling of α,α-diphenylpiperidino-4-methanol with a variety of aryl isothiocyanates[1]. |
| References |
| Molecular Formula | C27H31N3O3S2 |
|---|---|
| Molecular Weight | 509.68300 |
| Exact Mass | 509.18100 |
| PSA | 113.35000 |
| LogP | 5.37350 |
| Storage condition | -20°C |