622405-78-1

622405-78-1 structure

Name: m-PEG4-NHS ester
Chemical Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]propanoate
CAS Number: 622405-78-1
Molecular Formula: C₁₄H₂₃NO₈
Molecular Weight: 333.334
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-09-01 21:59:59
Modify Date: 2024-01-03 00:38:22
m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Name	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]propanoate
Synonyms	N-Succinimidyl 4,7,10,13-Tetraoxatetradecanoate 1-[(14-Oxo-2,5,8,11-tetraoxatetradecan-14-yl)oxy]-2,5-pyrrolidinedione Methyl-PEG4-NHS Ester 4,7,10,13-Tetraoxatetradecanoic Acid N-Succinimidyl Ester 2,5-Pyrrolidinedione, 1-[(1-oxo-4,7,10,13-tetraoxatetradec-1-yl)oxy]- AmbotzPEG1880 1-(4,7,10,13-tetraoxatetradecan-1-oyloxy)pyrrolidine-2,5-dione N-hydroxysuccinimidyl 3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-propanoate M2186

Description	m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

6066-82-6

848442-01-3

~70%

622405-78-1

Literature: BIOCON LIMITED Patent: US2011/118480 A1, 2011 ; Location in patent: Page/Page column 5 ;

112-35-6

622405-78-1

Literature: BIOCON LIMITED Patent: US2011/118480 A1, 2011 ;

883554-11-8

622405-78-1

Literature: BIOCON LIMITED Patent: US2011/118480 A1, 2011 ;

Precursor 3
6066-82-6 848442-01-3 112-35-6
DownStream 0