173323-22-3

173323-22-3 structure

Name: Bromoacetamide-PEG3-C1-acid
Chemical Name: 2-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]acetic acid
CAS Number: 173323-22-3
Molecular Formula: C₁₀H₁₈BrNO₆
Molecular Weight: 328.15700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-12-13 07:46:32
Modify Date: 2024-01-01 21:00:53
Bromoacetamide-PEG3-C1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]acetic acid
Synonyms	14-Bromo-13-oxo-3,6,9-trioxa-12-azatetradecan-1-oic acid Tatdabo OR8462

Description	Bromoacetamide-PEG3-C1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.