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16673-34-0

16673-34-0 structure
16673-34-0 structure
  • Name: NLRP3-IN-2
  • Chemical Name: 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzene Sulfonamide
  • CAS Number: 16673-34-0
  • Molecular Formula: C16H17ClN2O4S
  • Molecular Weight: 368.835
  • Catalog: Organic raw materials Amino compound Amide compound
  • Create Date: 2018-12-18 09:12:16
  • Modify Date: 2024-01-05 06:45:58
  • NLRP3-IN-2, an intermediate substrate in the synthesis of glyburide, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size following myocardial ischemia/reperfusion in the mouse, without affecting glucose metabolism[1].
Name 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzene Sulfonamide
Synonyms 5-chloro-2-methoxy-N-[2-(4-sulphamoylphenyl)ethyl]benzamide
Benzamide, N-[2-[4-(aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxy-
5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
4-[2-(5-chloro-2-methoxy-benzamide)ethyl]-benzenesulphonamide
EINECS 240-722-5
5-Chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide
MFCD00193756
Description NLRP3-IN-2, an intermediate substrate in the synthesis of glyburide, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size following myocardial ischemia/reperfusion in the mouse, without affecting glucose metabolism[1].
Related Catalog
In Vivo NLRP3-IN-2 is well tolerated with no effects on the glucose levels in vivo[1]. NLRP3-IN-2 (100 mg/kg) treatment in a model of AMI due to ischemia+reperfusion significantly inhibits the activity of inflammasome (caspase-1) in the heart by 90% (P<0.01) and reduced infarct size, measured at pathology (by >40%, P<0.01) and with troponin I levels (by >70%, P<0.01) [1]. Animal Model: Experimental acute myocardial infarction (AMI) model in mice[1]. Dosage: 100 mg/kg. Administration: Intraperitoneal administration 30 minutes prior to surgery, then every 6 hours for 3 additional doses. Result: Led to a significant >90% reduction in caspase-1 activity (reflective of the formation of an active inflammasome) in the heart tissue measured 24 hours after ischemia. Led to a significant reduction in the infarct size measured with TTC (>40% reduction) or troponin I levels (>70% reduction) when compared with vehicle alone.
References

[1]. Carlo Marchetti, et al. A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J Cardiovasc Pharmacol. 2014 Apr;63(4):316-322.
Density 1.4±0.1 g/cm3
Melting Point 209-214 °C
Molecular Formula C16H17ClN2O4S
Molecular Weight 368.835
Exact Mass 368.059753
PSA 106.87000
LogP 1.74
Index of Refraction 1.598
Storage condition Refrigerator
Hazard Codes T
Risk Phrases R23/24/25
Safety Phrases S26-S36-S36/37-S22
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2935009090
Precursor  2

DownStream  1

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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title: CAS No. 16673-34-0 | Chemsrc address: https://www.chemsrc.com/en/baike/667841.html

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