152918-18-8
152918-18-8 structure
- Name: IB-MECA
- Chemical Name: (2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]-N-methyloxolane-2-carboxamide
- CAS Number: 152918-18-8
- Molecular Formula: C18H19IN6O4
- Molecular Weight: 510.286
- Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
- Create Date: 2018-03-23 08:00:00
- Modify Date: 2024-01-11 11:36:57
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Piclidenoson (IB-MECA) is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM. IC50 value: 0.11 μM (EC50) [3]Target: adenosine A3 receptorin vitro: Piclidenoson has been shown to play important roles in cell proliferation and apoptosis in a variety of cancer cell lines. ThePiclidenoson was capable of decreasing intracellular cyclic adenosine monophosphate (cAMP) that was the reason for the presence of functional A3 adenosine receptor on the cell lines. Piclidenoson significantly reduced cell viability in a dose-dependent manner. Piclidenoson, an A3AR agonist, inhibits the growth of different cancer cell types like melanoma, colon, breast, leukemia, and prostatePiclidenoson was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 0.82 μM in OVCAR-3 cells. Piclidenoson was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 1.2 μM in Caov-4 cells.in vivo: Administrations of single intraperitoneal doses of either Piclidenoson 0.5 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice.[2]
| Name | (2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]-N-methyloxolane-2-carboxamide |
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| Synonyms |
UNII-30679UMI0N
Piclidenoson (2S,3S,4R,5R)-3,4-Dihydroxy-5-{6-[(3-iodobenzyl)amino]-9H-purin-9-yl}-N-methyltetrahydro-2-furancarboxamide IBMECA (2S,3S,4R,5R)-3,4-Dihydroxy-5-{6-[(3-iodobenzyl)amino]-9H-purin-9-yl}-N-methyltetrahydrofuran-2-carboxamide (non-preferred name) CF 101 3-IB-Meca IB-MECA CF101 |
| Description | Piclidenoson (IB-MECA) is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM. IC50 value: 0.11 μM (EC50) [3]Target: adenosine A3 receptorin vitro: Piclidenoson has been shown to play important roles in cell proliferation and apoptosis in a variety of cancer cell lines. ThePiclidenoson was capable of decreasing intracellular cyclic adenosine monophosphate (cAMP) that was the reason for the presence of functional A3 adenosine receptor on the cell lines. Piclidenoson significantly reduced cell viability in a dose-dependent manner. Piclidenoson, an A3AR agonist, inhibits the growth of different cancer cell types like melanoma, colon, breast, leukemia, and prostatePiclidenoson was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 0.82 μM in OVCAR-3 cells. Piclidenoson was able to inhibit forskolin-stimulated cAMP levels with an EC50 value of 1.2 μM in Caov-4 cells.in vivo: Administrations of single intraperitoneal doses of either Piclidenoson 0.5 h post-irradiation resulted in statistically significant increases of MST in comparison with the control irradiated mice.[2] |
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| Related Catalog | |
| References |
| Density | 2.0±0.1 g/cm3 |
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| Molecular Formula | C18H19IN6O4 |
| Molecular Weight | 510.286 |
| Exact Mass | 510.051239 |
| PSA | 134.42000 |
| LogP | 2.08 |
| Index of Refraction | 1.808 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| HS Code | 2934999090 |
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152918-18-8 |
| Literature: Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646 |
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152918-18-8 |
| Literature: Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646 |
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152918-18-8 |
| Literature: Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646 |
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152918-18-8 |
| Literature: Journal of Heterocyclic Chemistry, , vol. 37, # 2 p. 339 - 341 |
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152918-18-8 |
| Literature: Journal of Heterocyclic Chemistry, , vol. 37, # 2 p. 339 - 341 |
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152918-18-8 |
| Literature: Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646 |
| Precursor 5 | |
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| DownStream 1 | |
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |