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160003-66-7

160003-66-7 structure
160003-66-7 structure
  • Name: Iniparib (BSI-201)
  • Chemical Name: 4-Iodo-3-nitrobenzamide
  • CAS Number: 160003-66-7
  • Molecular Formula: C7H5IN2O3
  • Molecular Weight: 292.031
  • Catalog: Biochemical Inhibitor DNA damage PARP inhibitor
  • Create Date: 2018-05-01 08:00:00
  • Modify Date: 2024-01-03 16:05:42
  • Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer.
Name 4-Iodo-3-nitrobenzamide
Synonyms Iniparib (BSI-201)
4-Iodo-3-nitrobenzamide
Benzamide, 4-iodo-3-nitro-
Iniparib
BSI-201
Description Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer.
Related Catalog
Target

PARP1

In Vitro Iniparib nonselectively modifies cysteine-containing proteins in tumor cells[1]. Iniparib (100 μM) weakly inhibits SSB repair, and the inhibition can be reversed by knockdown of PARP1[2]. Iniparib in combination with cisplatin is cytotoxic to Myc/MDA-231 with EMT changes[3].
Cell Assay For nine day cell proliferation assay, MDA-MB-436 and MDA-MB-231 cells are plated at 2000 and 500 cells/well respectively in a 96-well plate and treated with veliparib, cmpd-A, cmpd-C, Iniparib or Iniparib-met at 0, 0.0001, 0.01,0.1, 1 or 10 μM for nine days. For five day cell proliferation assay, MDAMB-231 and MDA-MB-436 cells are plated at 1000 and 4000 cells/well respectively in a 96-well plate and treated with Iniparib or Iniparib-met at 0. 0.1, 0.3, 1, 3 or 10 μM in the presence of 0, 1.8, 3.75, or 7.5 µM BSO for 5 days. DLD1+/+ and DLD1-/- cells are plated at 1000 cells/well in a 96-well plate and treated with TMZ at 0, 0.003, 0.01, 0.03, 0.1, 0.3 or 1 mM in the presence of 0, 0.005, 0.05, 0.5, or 5 µM veliparib, or Iniparib for five days. After treatment, cell titer glow is carried out[1].
References

[1]. Liu X, et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res. 2012 Jan 15;18(2):510-23.

[2]. Ma W, et al. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5.

[3]. Yin S, et al. Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells. PLoS One. 2017 Aug 17;12(8):e0183578.
Density 2.1±0.1 g/cm3
Boiling Point 344.8±32.0 °C at 760 mmHg
Molecular Formula C7H5IN2O3
Molecular Weight 292.031
Flash Point 162.3±25.1 °C
Exact Mass 291.934479
PSA 88.91000
LogP 1.71
Appearance white to beige
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.696
Storage condition room temp
Water Solubility DMSO: soluble5mg/mL, clear
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xn
Risk Phrases 22-36-43
Safety Phrases 26
RIDADR NONH for all modes of transport
HS Code 2924299090
89976-27-2 structure

89976-27-2

~81%

160003-66-7 structure

160003-66-7

Literature: DIVI'S LABORATORIES LIMITED; Divi, Murali Krishna Prasad; Rao, Mysore Aswatha Narayana; Rajuri, Venkataramana Patent: US2013/172618 A1, 2013 ; Location in patent: Paragraph 0027; 0028 ;
1336-21-6 structure

1336-21-6

35674-27-2 structure

35674-27-2

~39%

160003-66-7 structure

160003-66-7

Literature: Octamer, Inc. Patent: US5877185 A1, 1999 ;
879-93-6 structure

879-93-6

~54%

160003-66-7 structure

160003-66-7

Literature: Cant, Alastair A.; Bhalla, Rajiv; Pimlott, Sally L.; Sutherland, Andrew Chemical Communications, 2012 , vol. 48, # 33 p. 3993 - 3995
35674-27-2 structure

35674-27-2

~%

160003-66-7 structure

160003-66-7

Literature: Journal of Organic Chemistry, , vol. 62, # 10 p. 3093 - 3097
HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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