905298-84-2

905298-84-2 structure

Name: LIMK1 inhibitor BMS-4
Chemical Name: 1-Ethyl-3-{5-[6-(4-methoxy-2,6-dimethylphenyl)-2-(2-pyrazinyl)-4- pyrimidinyl]-1,3-thiazol-2-yl}ure
CAS Number: 905298-84-2
Molecular Formula: C₂₃H₂₃N₇O₂S
Molecular Weight: 461.53900
Catalog: Signaling Pathways Cell Cycle/DNA Damage LIM Kinase (LIMK)
Create Date: 2016-02-13 16:16:11
Modify Date: 2024-01-17 21:56:08
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2].

Name	1-Ethyl-3-{5-[6-(4-methoxy-2,6-dimethylphenyl)-2-(2-pyrazinyl)-4- pyrimidinyl]-1,3-thiazol-2-yl}ure

Description	LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK)
Target	LIMK1:7.25 (pIC50) LIMK2:6.87 (pIC50)
In Vitro	LIMK1 inhibitor BMS-4 (compound 4) (0.014-10 μM; 24 h) 在体外抑制 LIMK 而不影响 A549 细胞存活或增殖[1]。 LIMK1 inhibitor BMS-4 (0.014-1 μM; 2 h) 在 A549 人肺癌细胞中抑制 LIMK 底物 cofilin 的磷酸化[1]。
References	[1]. Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65(20):13705-13713. [2]. Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8.