Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Myclobutanil
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Myclobutanil
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Myclobutanil
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DC Chemicals Limited
China
Product Name: Myclobutanil
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Myclobutanil
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Purity: 98.0%
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88671-89-0

88671-89-0 structure

88671-89-0 structure

Name: Myclobutanil
Chemical Name: myclobutanil
CAS Number: 88671-89-0
Molecular Formula: C₁₅H₁₇ClN₄
Molecular Weight: 288.775
Catalog: Chemical pesticide Fungicide Other fungicides
Create Date: 2018-07-17 19:12:51
Modify Date: 2024-01-02 18:40:24
Myclobutanil is a conazole class fungicide widely used as an agrichemical.

Name	myclobutanil
Synonyms	1H-1,2,4-Triazole-1-propanenitrile, α-butyl-α-(4-chlorophenyl)- α-Butyl-α-(4-chlorophenyl)-1H-1,2,4-triazole-1-propanenitrile Systhane Technical rac-(2R)-2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile 2-(4-Chlorphenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanonitril Synthane 12E 2-(4-Chlorophényl)-2-(1H-1,2,4-triazol-1-ylméthyl)hexanenitrile Nova W 2-(4-chlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)hexanenitrile 2-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile Systhane Systhane 6 Flo a-Butyl-a-(4-chlorophenyl)-1H-1,2,4-triazole-1-propanenitrile Rally (RS)-2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile MFCD00144818 T5NN DNJ A1X4&CN&R DG Myclobutanil

Description	Myclobutanil is a conazole class fungicide widely used as an agrichemical.
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection
In Vitro	Myclobutanil reduces cell viability to <50% at 100 ppm and to <10% at 500 ppm. Myclobutanil promotes a slight, but significant, increase in fatty acid (FA)-induced steatotosis at doses from 1 to 100 ppm. Anti-apoptotic biomarkers are significantly reduced by Myclobutanil[1].
Kinase Assay	To further evaluate apoptosis, cell extracts are collected after 24 h of exposure to Myclobutanil, centrifuged, and analyzed with a multiplex biometric ELISA-based immunoassay containing dyed microspheres conjugated to a monoclonal antibody specific for the target protein. Apoptosis biomarkers are BCL-xL/Bak dimer and Mcl-1/Bak dimer, quantified using RBM Apoptosis Panel 3. Each experiment is performed in triplicate and apoptosis biomarker levels determined using the Bio-Plex Array Reader. The analytic concentrations are calculated using a standard curve, according to the manufacturer’s instructions[1].
Cell Assay	The hepatoma cell line HepG2 is used in this study. The cells are grown on tissue culture plates in an incubator with a humidified atmosphere (95% air/5% CO2 v/v) at 37°C. Steatosis is induced by incubating the hepatocytes with 6 mM of a 1:1 v/v mixture of oleic (18:1) and linoleic (18:2) fatty acids (Fas) for 24 h. After a wash with PBS, cells are exposed for an additional 24 h to Myclobutanil at 0.1, 1, 10, 100 or 500 ppm. Cytotoxicity is assessed in HepG2 cells (1.0×105 cells/well in 24-well plates) by measuring the reduction of the tetrazolium dye 3-(4, 5-dimethylthiazol-2-yl)-5-(3carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTT)[1].
References	[1]. Stellavato A, et al. Myclobutanil worsens nonalcoholic fatty liver disease: An in vitro study of toxicity and apoptosis on HepG2 cells. Toxicol Lett. 2016 Nov 16;262:100-104.

Density	1.2±0.1 g/cm3
Boiling Point	465.2±55.0 °C at 760 mmHg
Melting Point	63-68°C
Molecular Formula	C₁₅H₁₇ClN₄
Molecular Weight	288.775
Flash Point	235.2±31.5 °C
Exact Mass	288.114166
PSA	54.50000
LogP	2.82
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.589
Storage condition	0-6°C
Water Solubility	142 mg/L (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ5257000

CHEMICAL NAME :: 1H-1,2,4-Triazole-1-propanenitrile, alpha-butyl-alpha-(4-chlorophenyl)-

CAS REGISTRY NUMBER :: 88671-89-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H17-Cl-N4

MOLECULAR WEIGHT :: 288.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,601,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C291,1991

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2229 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 40(242),9,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - other glands

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570641

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,55,1986

Symbol	GHS07, GHS08, GHS09
Signal Word	Warning
Hazard Statements	H302-H319-H361d-H411
Precautionary Statements	P273-P281-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36;R51/53;R63
Safety Phrases	S36/37-S46-S61
RIDADR	UN 3077
RTECS	XZ5257000
HS Code	2933990015

HS Code	2933990015
Summary	2933990015 3-((1h-1,2,4-triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%