Name | 3-(1-methylindol-3-yl)-4-(1-methyl-6-nitroindol-3-yl)pyrrole-2,5-dione |
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Synonyms |
MKC-1
UNII-DNZ11VPY7Q Bisindolylmaleimide deriv. 44 3-(1-methyl-3-indolyl)-4-(1-methyl-6-nitro-3-indolyl)-1H-pyrrole-2,5-dione Ro-31-7453 |
Description | MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family[1][2][3]. |
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Related Catalog | |
In Vivo | MKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors[3]. |
References |
Molecular Formula | C22H16N4O4 |
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Molecular Weight | 400.38700 |
Exact Mass | 400.11700 |
PSA | 105.34000 |
LogP | 3.94450 |