MKC-1

Modify Date: 2024-01-12 09:47:36

MKC-1 structure	Common Name	MKC-1
	CAS Number	125313-92-0	Molecular Weight	400.38700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₆N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MKC-1

MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family[1][2][3].

Name	3-(1-methylindol-3-yl)-4-(1-methyl-6-nitroindol-3-yl)pyrrole-2,5-dione
Synonym	More Synonyms

Description	MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family[1][2][3].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vivo	MKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors[3].
References	[1]. Wang M, et al. The first design and synthesis of [11C]MKC-1 ([11C]Ro 31-7453), a new potential PET cancer imaging agent. Nucl Med Biol. 2010 Oct;37(7):763-75. [2]. Faris JE, et al. A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer. Invest New Drugs. 2012 Aug;30(4):1614-20. [3]. Burke P, et al. MKC-1 significantly increases survival of mice bearing renal cell carcinoma Caki-1 xenograft tumors through inhibition of the Akt/mTOR pathway[J]. Molecular Cancer Therapeutics, 2007(12):3524S-3525S.

Molecular Formula	C₂₂H₁₆N₄O₄
Molecular Weight	400.38700
Exact Mass	400.11700
PSA	105.34000
LogP	3.94450

MKC-1

UNII-DNZ11VPY7Q

Bisindolylmaleimide deriv. 44

3-(1-methyl-3-indolyl)-4-(1-methyl-6-nitro-3-indolyl)-1H-pyrrole-2,5-dione

Ro-31-7453

MKC-1

Use of MKC-1

Names

MKC-1 Biological Activity

Chemical & Physical Properties

Synonyms