500-12-9

500-12-9 structure

Name: Goitrin
Chemical Name: (5S)-5-vinyl-1,3-oxazolidine-2-thione
CAS Number: 500-12-9
Molecular Formula: C₅H₇NOS
Molecular Weight: 129.18000
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2017-01-14 04:30:03
Modify Date: 2024-01-31 21:08:39
Goitrin ((S)-Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity[1][2][3].

Name	(5S)-5-vinyl-1,3-oxazolidine-2-thione
Synonyms	D,L-GOITRIN S-goitrin (S)-5-vinyl-oxazolidine-2-thione (S)-5-Vinyl-oxazolidin-2-thion goitrin MFCD00015467

Description	Goitrin ((S)-Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity[1][2][3].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Metabolic Disease
In Vitro	Goitrin (0.1-1 μM; 72 h) exhibits dose-dependent anti-influenza virus (H1N1) activity in Madin-Darby canine kidney (MDCK) cells, with an IC50 of 0.19 μM[3].
References	[1]. Felker P, et, al. Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism. Nutr Rev. 2016 Apr;74(4):248-58. [2]. Wooding S, et, al. Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables. Chem Senses. 2010 Oct;35(8):685-92. [3]. Nie LX, et, al. Antiviral activity of Isatidis Radix derived glucosinolate isomers and their breakdown products against influenza A in vitro/ovo and mechanism of action. J Ethnopharmacol. 2020 Apr 6;251:112550.

Hazard Codes	Xi
Safety Phrases	S24/25