949164-09-4

949164-09-4 structure

Name: ALX-1393
Chemical Name: O-[(2-benzyloxyphenyl)(3-fluorophenyl)methyl]-L-serine
CAS Number: 949164-09-4
Molecular Formula: C₂₃H₂₂FNO₄
Molecular Weight: 395.42300
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GlyT
Create Date: 2016-02-12 19:38:44
Modify Date: 2024-01-10 16:42:23
ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model[1].

Name	O-[(2-benzyloxyphenyl)(3-fluorophenyl)methyl]-L-serine

Description	ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GlyT
Target	GlyT2[1]
In Vivo	ALX1393 (i.c.v.; 25, 50, and 100 μg) in normal rats suppresses the late-phase response in the formalin test but does not affect motor performance. ALX1393 inhibits mechanical and cold hyperalgesia in a dose-dependent manner[2].
References	[1]. Haranishi Y, et al. The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model. Anesth Analg. 2010 Feb 1;110(2):615-21. [2]. Takahashi Y, et al. Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain. Pharmacol Biochem Behav. 2015 Mar;130:46-52.