ALX-1393

Modify Date: 2024-01-10 16:42:23

ALX-1393 Structure
ALX-1393 structure
Common Name ALX-1393
CAS Number 949164-09-4 Molecular Weight 395.42300
Density N/A Boiling Point N/A
Molecular Formula C23H22FNO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ALX-1393


ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model[1].

 Names

Name O-[(2-benzyloxyphenyl)(3-fluorophenyl)methyl]-L-serine

 ALX-1393 Biological Activity

Description ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model[1].
Related Catalog
Target

GlyT2[1]

In Vivo ALX1393 (i.c.v.; 25, 50, and 100 μg) in normal rats suppresses the late-phase response in the formalin test but does not affect motor performance. ALX1393 inhibits mechanical and cold hyperalgesia in a dose-dependent manner[2].
References

[1]. Haranishi Y, et al. The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model. Anesth Analg. 2010 Feb 1;110(2):615-21.

[2]. Takahashi Y, et al. Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain. Pharmacol Biochem Behav. 2015 Mar;130:46-52.

 Chemical & Physical Properties

Molecular Formula C23H22FNO4
Molecular Weight 395.42300
Exact Mass 395.15300
PSA 81.78000
LogP 4.62290
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