2747-05-9

2747-05-9 structure

Name: 7-Acetoxy-4-methylcoumarin
Chemical Name: 4-methylumbelliferyl acetate
CAS Number: 2747-05-9
Molecular Formula: C₁₂H₁₀O₄
Molecular Weight: 218.20500
Catalog: Chemical reagent Organic reagent Aromatic ketone
Create Date: 2018-07-20 11:04:56
Modify Date: 2024-01-11 20:50:20
7-Acetoxy-4-methylcoumarin is an inhibitor of GST.7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro with 36.7% inhibition[1][2].

Name	4-methylumbelliferyl acetate
Synonyms	4-Methylumbeliferyl acetate 4-Methylumbelliferyl Acetate 7-Aceoxy-4-MethylcouMarin EINECS 220-386-6 MUB ACETATE acetic acid 4-methyl-2-oxo-2H-chromen-7-yl ester 7-Acetoxy-4-methylcoumarin 7-ACETYL-4-METHYLCOUMARIN MUACETATE 4-METHYL-7-ACETOXYCOUMARIN 4-methyl-2-oxo-2H-chromen-7-yl acetate METHYLUMBELLIFERYL ACETATE 7-acetoxy-4-methyl-chromen-2-one MFCD00006865

Description	7-Acetoxy-4-methylcoumarin is an inhibitor of GST.7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro with 36.7% inhibition[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase
References	[1]. Feuer, G, et al. Induction of drug-metabolizing enzymes of rat liver by derivatives of coumarin. Canadian Journal of Physiology and Pharmacology, 48(4), 232–240. [2]. Raj HG, et al. Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom. Bioorg Med Chem. 2001 May;9(5):1085-9.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2932209090

90-33-5

108-24-7

~97%

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Literature: Bioorganic and Medicinal Chemistry, , vol. 13, # 5 p. 1605 - 1613

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64-19-7

~91%

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Literature: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 48, # 9 p. 1307 - 1310

108-46-3

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Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2> 24, p. 126

102-29-4

141-97-9

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Literature: Chemical Communications, , vol. 50, # 25 p. 3359 - 3362

89-84-9

108-24-7

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Literature: Chemische Berichte, , vol. 34, p. 107 Chemische Berichte, , vol. 25, p. 1304

90-33-5

75-36-5

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Literature: Tetrahedron Letters, , vol. 46, # 36 p. 6119 - 6121

90-33-5

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Literature: US6133460 A1, ;

108-24-7

141-97-9

108-46-3

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Literature: Journal of Sulfur Chemistry, , vol. 35, # 1 p. 31 - 41

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%