114495-97-5

114495-97-5 structure

Name: Neuropeptide Y (18-36) trifluoroacetate salt
Chemical Name: Neuropeptide Y (18-36), porcine
CAS Number: 114495-97-5
Molecular Formula: C₁₁₂H₁₇₄N₃₆O₂₇
Molecular Weight: 2456.80000
Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
Create Date: 2018-08-02 12:43:50
Modify Date: 2024-01-13 19:19:11
Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure[1].

Name	Neuropeptide Y (18-36), porcine

Description	Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
Target	IC50: 158 nM (I-NPY); Ki: 140 nM (I-NPY)[1]
In Vitro	Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM[1]. Neuropeptide Y (18-36) (porcine) (1 μM) shifts the inhibitory adenylate cyclase activity dose-response curve of NPY to the right in a parallel fashion[1]. Neuropeptide Y (18-36) (porcine) (1 μM) completely abolishes the effect of NPY (10 nM) that alone caused 80% of the maximum inhibition of adenylate cyclase activity[1].
References	[1]. A Balasubramaniam, et al. Neuropeptide Y (18-36) is a competitive antagonist of neuropeptide Y in rat cardiac ventricular membranes. J Biol Chem. 1990 Sep 5;265(25):14724-7.