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69123-98-4

69123-98-4 structure

Name: Fialuridine
Chemical Name: 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
CAS Number: 69123-98-4
Molecular Formula: C₉H₁₀FIN₂O₅
Molecular Weight: 372.09
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2018-09-26 13:58:58
Modify Date: 2024-01-02 13:02:41
Fialuridine is a nucleoside analog with antiviral activity[1].

Name	1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
Synonyms	1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil 1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione 1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione Fialuridine 5-Iodo-2'-fluoroarauracil 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo- 2'-Deoxy-2'-fluoro-5-iodouridine 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodouracil 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-

Description	Fialuridine is a nucleoside analog with antiviral activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
References	[1]. Mansuri MM, et al. 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent. J Med Chem. 1987 May;30(5):867-71.

Density	2.2±0.1 g/cm3
Melting Point	216-217ºC
Molecular Formula	C₉H₁₀FIN₂O₅
Molecular Weight	372.09
Exact Mass	371.961823
PSA	104.55000
LogP	-0.32
Index of Refraction	1.685
Storage condition	Refrigerator
Water Solubility	DMSO: soluble5mg/mL, clear (warmed)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ9512500

CHEMICAL NAME :: Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-

CAS REGISTRY NUMBER :: 69123-98-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H10-F-I-N2-O5

MOLECULAR WEIGHT :: 372.11

WISWESSER LINE NOTATION :: T6NVMVJ EI A- BT5OTJ CF DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 9100 ug/kg/13W-I

TOXIC EFFECTS :: Liver - jaundice, other or unclassified Liver - liver function tests impaired Nutritional and Gross Metabolic - metabolic acidosis

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 40 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,3957,1982

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
RTECS	YQ9512500
HS Code	2934999090

97614-45-4

~94%

69123-98-4

Literature: RESprotech GmbH Patent: US2010/227834 A1, 2010 ; Location in patent: Page/Page column 18 ;

69124-02-3

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Literature: US4211773 A1, ;

213136-12-0

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Literature: Journal of Organic Chemistry, , vol. 73, # 21 p. 8236 - 8243

97614-43-2

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Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 40, p. 91 - 93

97614-44-3

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Literature: Journal of Organic Chemistry, , vol. 50, # 19 p. 3644 - 3647

97614-42-1

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Literature: Journal of Organic Chemistry, , vol. 50, # 19 p. 3644 - 3647

98855-71-1

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Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 40, p. 91 - 93

Precursor 6
97614-45-4 69124-02-3 213136-12-0 97614-43-2
97614-44-3 97614-42-1
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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