6745-93-3

6745-93-3 structure

Name: D-AMETHOPTERIN HYDRATE
Chemical Name: d-amethopterin hydrate, 95
CAS Number: 6745-93-3
Molecular Formula: C₂₀H₂₄N₈O₆
Molecular Weight: 472.45500
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2017-06-19 13:04:32
Modify Date: 2024-01-06 07:42:37
Methotrexate (Amethopterin) monohydrate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

Name	d-amethopterin hydrate, 95
Synonyms	L-Glutamic acid,N-4-(2,4-diamino-6-pteridinyl)methylmethylaminobenzoyl-,monohydrate MTX hydrate

Description	Methotrexate (Amethopterin) monohydrate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Research Areas >> Inflammation/Immunology
Target	Traditional Cytotoxic Agents
In Vivo	Methotrexate (Amethopterin) monohydrate reduces thymus and spleen indices of mice. Methotrexate monohydrate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate monohydrate exposure on indices of thymus and spleens in mice[2]. Methotrexate (MTX) monohydrate (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate monohydrate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4].
References	[1]. Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73. [2]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. [3]. Ehab Tousson, et al. The Effect of L-carnitine on Amethopterin-induced Toxicity in Rat Large Intestine. [4]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550.

Melting Point	195ºC (dec.)(lit.)
Molecular Formula	C₂₀H₂₄N₈O₆
Molecular Weight	472.45500
Exact Mass	472.18200
PSA	210.98000
LogP	1.31280

Risk Phrases	46-60-61-25-36/37/38
Safety Phrases	53-22-26-36/37/39-45
RIDADR	UN 1544 6.1/PG 3

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