Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tolrestat
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Tolrestat
Price: $700.0/100mg $1400.0/250mg $2800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Tolrestat
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

82964-04-3

82964-04-3 structure

82964-04-3 structure

Name: Tolrestat
Chemical Name: tolrestat
CAS Number: 82964-04-3
Molecular Formula: C₁₆H₁₄F₃NO₃S
Molecular Weight: 357.348
Catalog: API Hormone and endocrine-regulating drugs Pancreatic hormones and other blood sugar regulating drugs
Create Date: 2018-03-03 08:00:00
Modify Date: 2024-01-03 22:24:08
Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.

Name	tolrestat
Synonyms	[(6-Methoxy-5-trifluoromethyl-naphthalene-1-carbothioyl)-methyl-amino]-acetic acid 2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid N-{[6-Methoxy-5-(trifluoromethyl)-1-naphthyl]carbothioyl}-N-methylglycine N-{[6-Methoxy-5-(trifluoromethyl)-1-naphthyl]carbonothioyl}-N-methylglycine N-[[6-Methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine AY-27,773 Tolrestatum [Latin] N-(6-Methoxythio-5-(trifluoromethyl)-1-naphthoyl)sarcosine Alredase N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]carbothioyl}-N-methylglycine Tolrestatum Tolrestat Glycine, N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methyl-

Description	Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase Research Areas >> Cancer
Target	IC50: 35 nM (Aldose Reductase)
In Vivo	Tolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats[1]. In 21-day diabetic rats, the estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil,respectively[2]. Either tolrestat or sorbinil inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice[3].
Animal Admin	For a period of four days, rats weighing about 70 g are given unlimited access to water and Chow supplemented with 20% (wt/wt) galactose and tolrestat at various dose levels. Rats used as control receive chow containing galactose (20%, wt/wt) or glucose (20%, wt/wt). The rats are killed; the lenses and sciatic nerves are removed and homogenized in 5% trichloroacetic acid; the deproteinized extracts are then analyzed for galactitol by a modification of a method for glycerol determination. The values obtained in the group fed 20% glucose are used for background correction.
References	[1]. Sestanj K, et al. N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor. J Med Chem. 1984 Mar;27(3):255-6. [2]. Simard-Duquesne N, et al. The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats. Metabolism. 1985 Oct;34(10):885-92. [3]. Srivastava S, et al. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 9;105(8):793-802.

Density	1.4±0.1 g/cm3
Boiling Point	498.1±55.0 °C at 760 mmHg
Melting Point	164-165°
Molecular Formula	C₁₆H₁₄F₃NO₃S
Molecular Weight	357.348
Flash Point	255.0±31.5 °C
Exact Mass	357.064636
PSA	81.86000
LogP	3.41
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.602
Storage condition	2-8℃