247923-29-1

247923-29-1 structure

Name: GW 9578
Chemical Name: 2-[4-[2-[(2,4-difluorophenyl)carbamoyl-heptylamino]ethyl]phenyl]sulfanyl-2-methylpropanoic acid
CAS Number: 247923-29-1
Molecular Formula: C₂₆H₃₄F₂N₂O₃S
Molecular Weight: 492.622
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2017-02-03 09:06:50
Modify Date: 2024-01-10 18:19:26
GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2].

Name	2-[4-[2-[(2,4-difluorophenyl)carbamoyl-heptylamino]ethyl]phenyl]sulfanyl-2-methylpropanoic acid
Synonyms	2-{[4-(2-{[(2,4-Difluorophenyl)carbamoyl](heptyl)amino}ethyl)phenyl]sulfanyl}-2-methylpropanoic acid gsk9578 unii-h32abl87x4 Propanoic acid, 2-[[4-[2-[[[(2,4-difluorophenyl)amino]carbonyl]heptylamino]ethyl]phenyl]thio]-2-methyl- gw 9578

Description	GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	mouse PPARα:5 nM (EC50) h-PPARα:50 nM (EC50)
In Vitro	GW9578 exhibits activities on Murine PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.005, 1.5, 2.6 μm, respectively. GW9578 exhibits activities on Human PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.05, 1, and 1.4 μm, respectively[2]. Treatment of the CD8+ T-cell line, TK.1 cells with GW9578 (10 nM-1 μM; for 24 hours) is able to induce a dose-dependent increase in the amount of relative luciferase activity[3]. Treatment of murine T-cell thymoma EL-4 T cells with GW9578 (10 nM-10 μM; for 2 hours) leads to a significant decrease in IL-2 production compared with control cells[3].
References	[1]. P J Brown, et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. J Med Chem. 1999 Sep 23;42(19):3785-8. [2]. Alexandre Trifilieff, et al. PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol. 2003 May;139(1):163-71. [3]. Dallas C Jones, et al. Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent. J Biol Chem. 2002 Mar 1;277(9):6838-45.

Density	1.2±0.1 g/cm3
Boiling Point	641.7±55.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₄F₂N₂O₃S
Molecular Weight	492.622
Flash Point	341.9±31.5 °C
Exact Mass	492.225830
PSA	94.94000
LogP	6.87
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.574

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