Name | Ondansetron hydrochloride |
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Synonyms |
2-Methylimdazole
ONDANSETRON HYDROCHLORIDE HYDRATE MFCD00833882 1H-Imidazole, 2-methyl- 2-Methyl-1H-imidazole methyl imidazole 2-Methylimidazole Ondansetron Hydrochloride ODANSETRON HYDROCHLORIDE Ondansetron Hydrochloride Dihydrate 2-methyl-imidazole Ondansetron HCl monohydrate Ondansetron (hydrochloride dihydrate) EINECS 600-465-5 |
Description | Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.Target: 5- HT3 ReceptorIC50 Value: in vitro: 5-HT evoked transient inward currents (EC50 = 3.4 microM; Hill coefficient = 1.8) that were blocked by the 5-HT3 receptor antagonist ondansetron (IC50 = 103 pM) [1]. The 5-HT3A receptor antagonist ondansetron (0.3 nM) reversibly inhibited the 5-HT (30 microM) signal by 70% and at 3 nM it abolished the response [2].in vivo: Acute ondansetron administration at the lowest dose (0.1 mg/kg, IP) tested had no effect, while other doses (0.33 and 1 mg/kg, IP) produced improvements in auditory gating [3]. Different doses of ondansetron were injected intraperitoneally (i.p.) at fixed times during the day to determine both the sublethal (TD50) and lethal (LD50) doses, which were, respectively, 3.7 +/- 0.6 mg/kg and 4.6 +/- 0.5 mg/kg [4]. ondansetron (0.25-1.0 mg/kg, subcutaneously) given before the challenge dose of ethanol (2.4 g/kg, intraperitoneally) injection, significantly and dose dependently attenuated the expression of sensitization. In addition, ondansetron (1.0 mg/kg, subcutaneously) given before ethanol injection on days 1, 4, 7, and 10 significantly blocked the development (days 1, 4, 7, and 10), and expression (day 15) of sensitization to the locomotor stimulant effect of ethanol injection [5]. Toxicity: Ondansetron may be safe in lower doses used to prevent nausea and vomiting in radiation treatment or postoperatively. However, as there is a report that a lower dose of ondansetron prolonged the QT interval in healthy volunteers, this needs to be clarified by the FDA [6]. |
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Related Catalog | |
References |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 267.0±9.0 °C at 760 mmHg |
Melting Point | 231-232ºC |
Molecular Formula | C18H24ClN3O3 |
Molecular Weight | 365.85 |
Flash Point | 144.9±5.1 °C |
PSA | 58.28000 |
LogP | -0.37 |
Vapour Pressure | 0.0±0.5 mmHg at 25°C |
Index of Refraction | 1.523 |
Storage condition | −20°C |
Symbol |
![]() ![]() ![]() GHS05, GHS06, GHS09 |
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Signal Word | Danger |
Hazard Statements | H301-H318-H410 |
Precautionary Statements | P273-P280-P301 + P310-P305 + P351 + P338-P501 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T:Toxic; |
Risk Phrases | R25 |
Safety Phrases | S45 |
RIDADR | UN 2811 |
RTECS | FE6375500 |