Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Phytic acid
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Phytic acid
Price: ￥98.0/20mg ￥228.0/500g ￥68.0/100g ￥278.0/500g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Phytic acid
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phytic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Phytic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

83-86-3

83-86-3 structure

83-86-3 structure

Name: Phytic acid
Chemical Name: myo-inositol hexakisphosphate
CAS Number: 83-86-3
Molecular Formula: C₆H₁₈O₂₄P₆
Molecular Weight: 660.04
Catalog: API Water, electrolyte and acid-base balance regulator Electrolyte balance regulator
Create Date: 2018-02-03 08:00:00
Modify Date: 2024-01-02 10:44:14
Phytic acid is a major phosphorus storage compound of most seeds and cereal grains.

Name	myo-inositol hexakisphosphate
Synonyms	myo-inositol-1,2,3,4,5,6-hexakis-dihydrogenphosphate Phytine Phyticacid Fytic acid inositol hexakisphosphate Alkalovert myo-Inositol hexaphosphate (2,3,4,5,6-pentaphosphonooxycyclohexyl) dihydrogen phosphate Inositol hexaphosphate Phytate myo-inositol 1,2,3,4,5,6-hexakisphosphate Alkovert 1,2,3,4,5,6-Cyclohexanehexol, hexakis(dihydrogen phosphate), sodium salt (1:12) Acidum fyticum MFCD00082309 Dodecasodium 1,2,3,4,5,6-cyclohexanehexayl hexakis(phosphate) EINECS 201-506-6

Description	Phytic acid is a major phosphorus storage compound of most seeds and cereal grains.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase Research Areas >> Inflammation/Immunology Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	Phytic acid, a major phosphorus storage compound of most seeds and cereal grains, contributes about 1 to 7% of their dry weight. It may account for more than 70% of the total kernel phosphorus. Phytic acid has the strong ability to chelate multivalent metal ions, especially zinc, calcium, and iron. The binding can result in very insoluble salts that are poorly absorbed from the gastrointestinal tract, which results in poor bioavailability of minerals. Phytic acid is also considered to be a natural antioxidant and is suggested to have potential functions of reducing lipid peroxidation and as a preservative in foods[1]. Phytic acid inhibits the formation of uric acid from xanthine with an IC50 of about 30 mM. The generation of the superoxide is greatly affected by phytic acid; the IC50 is about 6 mM, indicating that the superoxide generating domain of XO is more sensitive to phytic acid[2]. There has been observed an inhibition of tumor growth and induction of cell differentiation in the presence of phytic acid in a few cancer cell lines including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma and glioblastoma[3].
In Vivo	Phytic acid has a neuroprotective effect in MPTP-induced PD model and the neuroprotection is correlated with its anti-inflammatory effect which may be associated with suppression of pathways that involved in NF-κB and p-ERK. Phytic acid significantly inhibits MPTP-induced dopaminergic cell loss in the substantia nigra (SN). Moreover, using immunohistochemistry method and quantitative polymerase chain reaction (qPCR), microglial activation and inducible nitric oxide synthase (iNOS) are found to be markedly repressed by phytic acid[4].
Animal Admin	Mice: MPTP (20 mg/kg/day, i.p.) is administrated for 5 days and animals are killed at 7 days later. Phytic acid (30 mg/kg/day, i.p.) or normalsaline is injected 4 days before MPTP administration and con-tinued until mice are killed, reaching a total treatment period of16 days[4].
References	[1]. Zhou JR, et al. Phytic acid in health and disease. Crit Rev Food Sci Nutr. 1995 Nov;35(6):495-508. [2]. Muraoka S, et al. Inhibition of xanthine oxidase by phytic acid and its antioxidative action. Life Sci. 2004 Feb 13;74(13):1691-700. [3]. Nawrocka-Musial D, et al. Phytic acid--anticancer nutriceutic. Pol Merkur Lekarski. 2012 Jul;33(193):43-7. [4]. Lv Y, et al. Phytic acid attenuates inflammatory responses and the levels of NF-κB and p-ERK in MPTP-induced Parkinson's disease model of mice. Neurosci Lett. 2015 Jun 15;597:132-6.

Density	2.4±0.1 g/cm3
Boiling Point	1190.7±75.0 °C at 760 mmHg
Molecular Formula	C₆H₁₈O₂₄P₆
Molecular Weight	660.04
Flash Point	673.9±37.1 °C
PSA	459.42000
LogP	-8.47
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.629
Storage condition	Refrigerator
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	MISCIBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM7525000

CHEMICAL NAME :: Inositol, hexakis(dihydrogen phosphate), myo-

CAS REGISTRY NUMBER :: 83-86-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H18-O24-P6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 22,279,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H290-H314-H335
Precautionary Statements	P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	1760
WGK Germany	-
RTECS	NM7525000
Packaging Group	III
Hazard Class	8
HS Code	2919900090

551-72-4 structure

551-72-4

~%

83-86-3 structure

83-86-3

Literature: Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 169, p. 138 Helvetica Chimica Acta, , vol. 4, p. 158

87-89-8 structure

87-89-8

7664-38-2 structure

7664-38-2

~%

83-86-3 structure

83-86-3

Literature: Helvetica Chimica Acta, , vol. 4, p. 164

Precursor 3
551-72-4 87-89-8 7664-38-2
DownStream 3
87-89-8 98-01-1 7664-38-2

HS Code	2919900090
Summary	2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%