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Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: Prothanon
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13754-56-8

13754-56-8 structure

13754-56-8 structure

Name: Dioxopromethazine
Chemical Name: 1-(5,5-dioxophenothiazin-10-yl)-N,N-dimethylpropan-2-amine
CAS Number: 13754-56-8
Molecular Formula: C₁₇H₂₀N₂O₂S
Molecular Weight: 316.418
Catalog: API Antiallergic Antihistamine
Create Date: 2018-09-07 16:51:33
Modify Date: 2024-01-09 14:07:04
Dioxopromethazine is an orally active antihistamine. Dioxopromethazine inhibits asthmatic symptoms[1].

Name	1-(5,5-dioxophenothiazin-10-yl)-N,N-dimethylpropan-2-amine
Synonyms	UNII:6OOT1MR6XS 9,9-Dioxypromethazin 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, 5,5-dioxide (9CI) 9,9-Dioxopromethazine 1-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N-dimethyl-2-propanamine Promethazine SS oxide Dioxopromethazine Promethazine 5,5-dioxide Prothanon 1-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N-dimethylpropan-2-amine 9,9-Dioxopromethazin 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, 5,5-dioxide

Description	Dioxopromethazine is an orally active antihistamine. Dioxopromethazine inhibits asthmatic symptoms[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
References	[1]. Bartsch R, et al. Zur Pharmakologie des neuen Antihistaminicums 9.9-Dioxopromethazin (Prothanon) [Pharmacology of the new antihistaminic 9,9-dioxopromethazine (Prothanon)]. Pharmazie. 1970;25(2):91-96.

Density	1.2±0.1 g/cm3
Boiling Point	478.5±34.0 °C at 760 mmHg
Melting Point	127-129ºC
Molecular Formula	C₁₇H₂₀N₂O₂S
Molecular Weight	316.418
Flash Point	243.2±25.7 °C
Exact Mass	316.124542
PSA	49.00000
LogP	2.18
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.606

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO7350000

CHEMICAL NAME :: Phenothiazine, 10-(2-(dimethylamino)propyl)-, 5,5-dioxide, monohydrochloride

CAS REGISTRY NUMBER :: 13754-56-8

LAST UPDATED :: 199503

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C17-H20-N2-O2-S.Cl-H

MOLECULAR WEIGHT :: 352.91

WISWESSER LINE NOTATION :: T C666 BN ISWJ B3N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18,155,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 49 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 96 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 18,155,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 25,91,1970