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93107-08-5

93107-08-5 structure
93107-08-5 structure
  • Name: Ciprofloxacin Hydrochloride
  • Chemical Name: Ciprofloxacin (hydrochloride)
  • CAS Number: 93107-08-5
  • Molecular Formula: C17H19ClFN3O3
  • Molecular Weight: 367.802
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2018-03-27 08:00:00
  • Modify Date: 2024-01-02 18:14:36
  • Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
Name Ciprofloxacin (hydrochloride)
Synonyms 1-Cyclopropyl-6-fluor-4-oxo-7-piperazin-1-yl-1,4-dihydrochinolin-3-carbonsäurehydrochlorid
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride (1:1)
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acid hydrochloride
1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1)
ciprofloxacinium chloride
1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride (1:1)
acide 1-cyclopropyl-6-fluoro-4-oxo-7-pipérazin-1-yl-1,4-dihydroquinoléine-3-carboxylique chlorhydrate
Cyproxan
1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
Ciprofloxacin Hydrochloride
4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)piperazin-1-ium chloride
ciprofloxacin monohydrochloride
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid
Ciprofloxacin Hcl
BAY-o-9867
Description Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
Related Catalog
Target

Bacterial[1]

In Vitro Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1]. Ciprofloxacin hydrochloride (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2].
In Vivo Ciprofloxacin hydrochloride (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin hydrochloride (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae[1]. In a murine model of pneumonic plague, Ciprofloxacin hydrochloride (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin hydrochloride. Intraperitoneal Ciprofloxacin hydrochloride reduces the lung bacterial load compare to controls treated with intraperitoneal PBS[3].
Cell Assay Bacterial inocula are prepared by suspending colonies into Mueller-Hinton broth (CAMHB) (containing Ciprofloxacin hydrochloride) from 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) on sheep blood agar (SBA) plates that are incubated at 35°C. Suspended cultures are diluted with CAMHB to a bacterial cell density of 105 CFU/mL adjusted based on the optical density at 600 nm. To each well of the 96-well plate, 50 μL of dilutions is added for a final inoculum of ~5×104 CFU/well. Plates are incubated at 35°C. MICs are determined visually at 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) and also by absorbance at 600 nm[2].
Animal Admin Female BALB/cAnNCrl (BALB/c) mice, 8 to 10 weeks old and 20 g (±4 g) are used in this assay. A single dose of Ciprofloxacin hydrochloride (30 mg/kg) is administered to mice (n=30) via the intraperitoneal (i.p.) route. The mice (n=3/time point/group) are culled at 1, 10, 20, or 30 min and 1, 1.5, 2, 4, 8, 12 h following Ciprofloxacin hydrochloride administration and 1, 15, or 30 min and 1, 2, 4, 6, 10, 18, or 24 h following DRCFI or CFI administration. Blood sampling points are chosen based upon the short half-life of Ciprofloxacin hydrochloride and longer half-life of CFI. Blood and lungs (whole organ) are collected post mortem for analysis. The lung doses following CFI or DRCFI administration are calculated using the concentration of Ciprofloxacin hydrochloride in the lung samples at 1 min post-administration[3].
References

[1]. Peltzer PM, et al. Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae. Environ Toxicol Pharmacol. 2017 Feb 4. pii: S1382-6689(17)30029-7.

[2]. Steenbergen J, et al. In Vitro and In Vivo Activity of Omadacycline Against Two Biothreat Pathogens: Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Feb 21.

[3]. Hamblin KA, et al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91.
Boiling Point 581.8ºC at 760 mmHg
Melting Point >300ºC
Molecular Formula C17H19ClFN3O3
Molecular Weight 367.802
Flash Point 305.6ºC
Exact Mass 367.109894
PSA 74.57000
LogP 2.77910
Storage condition 2-8C
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
HS Code 29419000
HS Code 29419000

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title: CAS No. 93107-08-5 | Chemsrc address: https://www.chemsrc.com/en/baike/964961.html

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