1092679-51-0

1092679-51-0 structure

Name: WAY-100635 Maleate
Chemical Name: WAY-100635 Maleate
CAS Number: 1092679-51-0
Molecular Formula: C₂₉H₃₈N₄O₆
Molecular Weight: 538.635
Catalog: Biochemical Inhibitor Neuronal Signaling 5-HT Receptor Agonist
Create Date: 2016-06-17 18:30:27
Modify Date: 2024-01-08 11:14:24
WAY-100635 Maleate is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71.

Name	WAY-100635 Maleate
Synonyms	Cyclohexanecarboxamide, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1) N-{2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl}-N-(2-pyridinyl)cyclohexanecarboxamide (2Z)-2-butenedioate (1:1) N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (2Z)-but-2-enedioate (1:1) Cyclohexanecarboxamide (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl WAY100635

Description	WAY-100635 Maleate is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
Target	5-HT1A Receptor:8.87 (pIC50) 5-HT1A Receptor:9.71 (pA2)
In Vitro	WAY-100635 Maleate is a potent and, at high concentrations, an insurmountable antagonist of the 5-HT1A receptor agonist action of 5-carboxamidotryptamine, with an apparent pA2 value (at 0.3 nM) of 9.71. WAY-100635 displaces specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a plCIC50 of 8.87[1].
References	[1]. Forster EA, et al. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur J Pharmacol. 1995 Jul 25;281(1):81-8.