Wurster's blue

Modify Date: 2024-01-12 12:24:50

Wurster's blue Structure
Wurster's blue structure
Common Name Wurster's blue
CAS Number 100-22-1 Molecular Weight 164.25
Density 1.0±0.1 g/cm3 Boiling Point 260.6±13.0 °C at 760 mmHg
Molecular Formula C10H16N2 Melting Point 49-51 °C(lit.)
MSDS USA Flash Point 104.9±7.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Wurster's blue


N,N,N′,N′-Tetramethyl-p-phenylenediamine (TMPD) is an redox indicator. N,N,N′,N′-Tetramethyl-p-phenylenediamine can be used for the research of impairment of cell respiration[1][2].

 Names

Name N,N,N',N'-Tetramethyl-1,4-phenylenediamine
Synonym More Synonyms

 Wurster's blue Biological Activity

Description N,N,N′,N′-Tetramethyl-p-phenylenediamine (TMPD) is an redox indicator. N,N,N′,N′-Tetramethyl-p-phenylenediamine can be used for the research of impairment of cell respiration[1][2].
Related Catalog
References

[1]. Zhou S, Yao Y, et al. A cytochrome c-enhanced peroxidation reaction with potential use in screening dietary antioxidants. J Pharm Biomed Anal. 2004 Mar 10;34(5):1057-61.  

[2]. Sarti P, et al. Permeability of rat heart myocytes to cytochrome c. Cell Mol Life Sci. 1999 Dec;56(11-12):1061-9.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 260.6±13.0 °C at 760 mmHg
Melting Point 49-51 °C(lit.)
Molecular Formula C10H16N2
Molecular Weight 164.25
Flash Point 104.9±7.7 °C
Exact Mass 164.131348
PSA 6.48000
LogP 2.08
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.578
Stability Stable, but may be air or light sensitive. Combustible. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.
Water Solubility slightly in cold, more in hot water

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ST4200000
CHEMICAL NAME :
p-Phenylenediamine, N,N,N',N'-tetramethyl-
CAS REGISTRY NUMBER :
100-22-1
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C10-H16-N2
MOLECULAR WEIGHT :
164.28
WISWESSER LINE NOTATION :
1N1&R DN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
780 mg/m3/10M
TOXIC EFFECTS :
Behavioral - irritability Lungs, Thorax, or Respiration - acute pulmonary edema
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
23700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,175,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3675 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 232 (estimated) No. of Female Employees: 130 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22
Safety Phrases S28-S28A
RIDADR UN 2811 6.1/PG 3
WGK Germany 1
RTECS ST4200000
Packaging Group II
Hazard Class 6.1(a)
HS Code 2921519090

 Synthetic Route

 Customs

HS Code 2921519090
Summary 2921519090. o-, m-, p-phenylenediamine, diaminotoluenes, and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles11

More Articles
Cation binding site of cytochrome c oxidase: progress report.

Biochim. Biophys. Acta 1837(7) , 1188-95, (2014)

Cytochrome c oxidase from bovine heart binds Ca(2+) reversibly at a specific Cation Binding Site located near the outer face of the mitochondrial membrane. Ca(2+) shifts the absorption spectrum of hem...

Re-evaluation of the near infrared spectra of mitochondrial cytochrome c oxidase: Implications for non invasive in vivo monitoring of tissues.

Biochim. Biophys. Acta 1837(11) , 1882-91, (2014)

We re-determined the near infrared (NIR) spectral signatures (650-980nm) of the different cytochrome c oxidase redox centres, in the process separating them into their component species. We confirm th...

Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.

Eur. J. Med. Chem. 101 , 81-95, (2015)

A series of triazin-3(2H)-one derivatives bearing 1,3,4-oxadiazole (4a-4o) were synthesized, characterized and evaluated for anti-inflammatory and analgesic activities. Preliminary in vitro anti-infla...

 Synonyms

1,4-Benzenediamine, N,N,N,N-tetramethyl-
tetramethylphenylenediamine
Wurster's blue
N,N,N′,N′-tetramethyl-p-phenylenediamine
EINECS 202-831-6
N,N,N‘,N‘-Tetramethyl-p-phenylenediamine
N,N,N',N'-Tetramethyl-1,4-benzenediamine
N,N,N′,N′-tetramethyl-para-phenylenediamine
1-N,1-N,4-N,4-N-tetramethylbenzene-1,4-diamine
N,N,N′,N′-Tetramethyl-1,4-phenylenediamine
MFCD00008309
n,n,n',n'-tetramethyl-p-phenylenediamine
N,N,N',N'-tetramethylbenzene-1,4-diamine
N,N,N,N-Tetramethyl-p-phenylenediamine
1,4-bis(dimethylamino)benzene
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