TCS 2002
Modify Date: 2024-01-08 11:26:40
TCS 2002 structure
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Common Name | TCS 2002 | ||
|---|---|---|---|---|
| CAS Number | 1005201-24-0 | Molecular Weight | 338.38000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H14N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TCS 2002GSK-3β inhibitor 9 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. GSK-3β inhibitor 9 shows good pharmacokinetic profiles including favorable BBB penetration. GSK-3β inhibitor 9 can be used for the research of Alzheimer’s disease[1]. |
| Name | 2-methyl-5-[3-(4-methylsulfinylphenyl)-1-benzofuran-5-yl]-1,3,4-oxadiazole |
|---|---|
| Synonym | More Synonyms |
| Description | GSK-3β inhibitor 9 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. GSK-3β inhibitor 9 shows good pharmacokinetic profiles including favorable BBB penetration. GSK-3β inhibitor 9 can be used for the research of Alzheimer’s disease[1]. |
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| Related Catalog | |
| Target |
GSK-3:35 nM (IC50) |
| In Vivo | GSK-3β inhibitor 9 (Compound 9b) (1-3 mg/kg;1-24 hours; GS rats andC57BL/6N mice) exhibits good pharmacokinetic profiles and favor able BBB permeability with AUC0-24h value is 734 ng•h/g and Kp value (ratio of brain and plasma) is 1.6[1]. Animal Model: IGS rats (male, 8 weeks old)[1] Dosage: 1 and 3mg/kg Administration: Intravenous injection and oral administration;for 1, 2, 4, 8, 24 hours. Result: 1.19 comp (S)-9b (S)-9c VDSS,iv (mL/kg) 1134 1650 CLtotal,iv (mL/min/kg) 27.4 28.4 Cmax,po (ng/mL) 396.9 289.6 AUC0-24 h,po (ng·h/mL) 1380.6 1229.1 MRTpo (h) 2.19 3.03 Fd (%) 72.8 65.5 |
| References |
| Molecular Formula | C18H14N2O3S |
|---|---|
| Molecular Weight | 338.38000 |
| Exact Mass | 338.07300 |
| PSA | 88.34000 |
| LogP | 5.06130 |
|
~85%
TCS 2002 CAS#:1005201-24-0 |
| Literature: Itoh, Fumio Patent: US2010/69381 A1, 2010 ; Location in patent: Page/Page column 102 ; |
| 2-methyl-5-{3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl}-1,3,4-oxadiazole |
| 1,3,4-Oxadiazole,2-methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl] |