Isocytosine

Modify Date: 2024-01-03 15:20:07

Isocytosine structure	Common Name	Isocytosine
	CAS Number	108-53-2	Molecular Weight	111.102
	Density	1.5±0.1 g/cm3	Boiling Point	393.6±34.0 °C at 760 mmHg
	Molecular Formula	C₄H₅N₃O	Melting Point	275°C
	MSDS	Chinese USA	Flash Point	191.9±25.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Isocytosine

Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA[1][2].

Name	2-amino-4-hydroxypyrimidine
Synonym	More Synonyms

Description	Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. "Isocytosine". Molecule of the Week. American Chemical Society. Retrieved November 1, 2012. [2]. Hoshika S, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science. 2019 Feb 22;363(6429):884-887.

Description

Related Catalog

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

References

[1]. "Isocytosine". Molecule of the Week. American Chemical Society. Retrieved November 1, 2012.

[2]. Hoshika S, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science. 2019 Feb 22;363(6429):884-887.

Density	1.5±0.1 g/cm3
Boiling Point	393.6±34.0 °C at 760 mmHg
Melting Point	275°C
Molecular Formula	C₄H₅N₃O
Molecular Weight	111.102
Flash Point	191.9±25.7 °C
Exact Mass	111.043259
PSA	72.03000
LogP	-1.01
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.668
Storage condition	Room temperature.

Isocytosine MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933599090

Precursor 10
CAS#:874-14-6 1,3-Dimethyluracil CAS#:50-01-1 Guanidine hydro... CAS#:617-48-1 (±)-Malic Acid CAS#:113-00-8 guanidine
CAS#:109-12-6 2-Aminopyrimidine CAS#:77287-34-4 (Z)-Methanimidi... CAS#:55662-68-5 Imidazo[1,2-a]p... CAS#:25957-58-8 4-ETHOXY-2-HYDR...
CAS#:3993-78-0 2-Amino-4-chlor... CAS#:5751-20-2 2-Methylthio-4-...
DownStream 8
CAS#:3993-78-0 2-Amino-4-chlor... CAS#:66-22-8 Uracil CAS#:61937-71-1 2-amino-5-bromo... CAS#:55662-68-5 Imidazo[1,2-a]p...
CAS#:55662-33-4 imidazolopyrimi... CAS#:108-53-2 Isocytosine CAS#:7254-29-7 4(1H)-Pyrimidin... CAS#:629645-53-0 tert-butyl (4-h...

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Lead optimization of isocytosine-derived xanthine oxidase inhibitors.

Bioorg. Med. Chem. Lett. 23(3) , 834-8, (2013)

We report our attempts at improving the oral efficacy of low-nanomolar inhibitors of xanthine oxidase from isocytosine series through chemical modifications. Our lead compound had earlier shown good i...

Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia

Bioorg. Med. Chem. Lett. 22(24) , 7543-6, (2012)

Structure-activity relationship studies were carried out for lead generation following structure-guided design approach from an isocytosine scaffold identified earlier for xanthine oxidase inhibition....

Indirect photochemical transformations of acyclovir and penciclovir in aquatic environments increase ecological risk.

Environ. Toxicol. Chem. 35 , 584-92, (2016)

Acyclovir and penciclovir, 2 antiviral drugs, are increasingly detected in aquatic environments. The present study explores the natural photochemical transformation mechanisms and fate of these drugs,...

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Isocytosine

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MFCD00057557

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EINECS 203-592-0

2-aminouracil

4-Pyrimidinol, 2-amino-

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China
Product Name: Isocytosine
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Price: ￥550/10 mM * 1 mL in DMSO

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Isocytosine

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