Bis-propargyl-PEG8

Modify Date: 2024-01-11 10:12:54

Bis-propargyl-PEG8 Structure
Bis-propargyl-PEG8 structure
Common Name Bis-propargyl-PEG8
CAS Number 1092554-87-4 Molecular Weight 446.532
Density 1.1±0.1 g/cm3 Boiling Point 495.5±40.0 °C at 760 mmHg
Molecular Formula C22H38O9 Melting Point N/A
MSDS N/A Flash Point 187.0±27.2 °C

 Use of Bis-propargyl-PEG8


Bis-propargyl-PEG8 (compound 16e) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

 Names

Name 4,7,10,13,16,19,22,25,28-Nonaoxahentriaconta-1,30-diyne
Synonym More Synonyms

 Bis-propargyl-PEG8 Biological Activity

Description Bis-propargyl-PEG8 (compound 16e) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Jervis PJ, et al. Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues. Carbohydr Res. 2012 Jul 15;356:152-62.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 495.5±40.0 °C at 760 mmHg
Molecular Formula C22H38O9
Molecular Weight 446.532
Flash Point 187.0±27.2 °C
Exact Mass 446.251587
LogP -1.85
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.466
Storage condition 2-8°C

 Synonyms

MFCD27635156
4,7,10,13,16,19,22,25,28-Nonaoxahentriaconta-1,30-diyne
Bis-propargyl-PEG8
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