m-PEG4-propargyl

Modify Date: 2024-09-06 20:45:56

m-PEG4-propargyl Structure
m-PEG4-propargyl structure
Common Name m-PEG4-propargyl
CAS Number 1101668-39-6 Molecular Weight 246.300
Density 1.0±0.1 g/cm3 Boiling Point 304.2±32.0 °C at 760 mmHg
Molecular Formula C12H22O5 Melting Point N/A
MSDS N/A Flash Point 115.2±25.0 °C

 Use of m-PEG4-propargyl


m-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

 Names

Name 2,5,8,11,14-Pentaoxaheptadec-16-yne
Synonym More Synonyms

 m-PEG4-propargyl Biological Activity

Description m-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 304.2±32.0 °C at 760 mmHg
Molecular Formula C12H22O5
Molecular Weight 246.300
Flash Point 115.2±25.0 °C
Exact Mass 246.146729
LogP -0.96
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.443
Storage condition 2-8°C

 Synonyms

2,5,8,11,14-Pentaoxaheptadec-16-yne
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