DOLASTATIN 10
Modify Date: 2024-01-05 16:14:41
DOLASTATIN 10 structure
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Common Name | DOLASTATIN 10 | ||
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| CAS Number | 110417-88-4 | Molecular Weight | 785.091 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 903.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C42H68N6O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 500.3±34.3 °C | |
Use of DOLASTATIN 10Dolastatin 10 is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization. |
| Name | L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl] amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]] |
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| Synonym | More Synonyms |
| Description | Dolastatin 10 is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization. |
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| Related Catalog | |
| Target |
Tubulin[1] |
| In Vitro | Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50 values of 10−5-10−6 μg/mL (10−2-10−3 nM) against a similar minipanel of human cell lines[2]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[3]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 903.6±65.0 °C at 760 mmHg |
| Molecular Formula | C42H68N6O6S |
| Molecular Weight | 785.091 |
| Flash Point | 500.3±34.3 °C |
| Exact Mass | 784.492126 |
| PSA | 161.65000 |
| LogP | 6.44 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.537 |
| Storage condition | -20°C |
| RIDADR | UN 3172 |
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| Packaging Group | III |
| Hazard Class | 6.1(b) |
| D-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl- |
| N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]-1-pyrrolidinyl}-5-methyl-1-oxo-4-heptanyl]-N-methyl-D-valinamide |
| dolastatin 10 |
| From dolabella auricularia (sea hare) |
| N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-D-valinamide |