ELOVL6-IN-1

Modify Date: 2024-01-12 12:34:28

ELOVL6-IN-1 structure	Common Name	ELOVL6-IN-1
	CAS Number	1185736-98-4	Molecular Weight	495.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₄F₃N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ELOVL6-IN-1

ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].

Name	ELOVL6-IN-1

Description	ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50: 0.35 μM (ELOVL6), Ki: 994 nM (ELOVL6)[1]
In Vitro	ELOVL6-IN-1 has sufficiently lipophilic having the potential to penetrate the intracellular space in a passive diffusion manner[1].
In Vivo	ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1]. ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1]. ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1]. Animal Model: C57BL/6J mice Dosage: 10 mg/kg Administration: P.o. Result: Displayed appreciable plasma and liver exposure. Animal Model: C57BL/6J mice Dosage: 10 and 30 mg/kg Administration: P.o. Result: Reduced the elongation index of the liver lipids. Animal Model: C57BL/6J mice Dosage: 100 mg/kg Administration: P.o. Result: Reduced the elongation index of the total fatty acids of the liver.
References	[1]. Shimamura K, et al. 5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool. J Pharmacol Exp Ther. 2009;330(1):249-256.

Molecular Formula	C₂₇H₂₄F₃N₃O₃
Molecular Weight	495.49

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ELOVL6-IN-1
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

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Price: ￥3820/10 mM * 1 mL in DMSO

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ELOVL6-IN-1

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