SIRT-IN-3

Modify Date: 2024-01-10 09:32:34

SIRT-IN-3 Structure
SIRT-IN-3 structure
 Common Name SIRT-IN-3
CAS Number 1211-19-4 Molecular Weight 212.24700
Density 1.218g/cm3 Boiling Point 413.3ºC at 760 mmHg
Molecular Formula C13H12N2O Melting Point N/A
MSDS N/A Flash Point 203.8ºC

 Use of SIRT-IN-3


SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1].

 Names

Name 2-anilinobenzamide
Synonym More Synonyms

 SIRT-IN-3 Biological Activity

Description SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively)[1].
Related Catalog
In Vitro SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells[1].
References

[1]. Suzuki T, et al. 2-Anilinobenzamides as SIRT inhibitors. ChemMedChem. 2006 Oct;1(10):1059-62.

 Chemical & Physical Properties

Density 1.218g/cm3
Boiling Point 413.3ºC at 760 mmHg
Molecular Formula C13H12N2O
Molecular Weight 212.24700
Flash Point 203.8ºC
Exact Mass 212.09500
PSA 55.12000
LogP 3.30240
Vapour Pressure 4.84E-07mmHg at 25°C
Index of Refraction 1.663

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CV2340485
CHEMICAL NAME :
Benzamide, o-anilino-
CAS REGISTRY NUMBER :
1211-19-4
BEILSTEIN REFERENCE NO. :
0782669
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H12-N2-O
MOLECULAR WEIGHT :
212.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Behavioral - ataxia Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 60,703,1971

 Safety Information

HS Code 2924299090

 Synthetic Route

Bromobenzene structure

Bromobenzene

CAS#:108-86-1

Benzenecarboximidic acid, 2-amino- (9CI) structure

Benzenecarboxim...

CAS#:28144-70-9

~80%

SIRT-IN-3 Structure

SIRT-IN-3

CAS#:1211-19-4

Literature: Huang, Xiaohua; Anderson, Kevin W.; Zim, Danilo; Jiang, Lei; Klapars, Artis; Buchwald, Stephen L. Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6653 - 6655
Bromobenzene structure

Bromobenzene

CAS#:108-86-1

Benzenecarboximidic acid, 2-amino- (9CI) structure

Benzenecarboxim...

CAS#:28144-70-9

~0%

SIRT-IN-3 Structure

SIRT-IN-3

CAS#:1211-19-4

2'-aminobenzanilide structure

2'-aminobenzanilide

CAS#:4424-17-3

Literature: Huang, Xiaohua; Anderson, Kevin W.; Zim, Danilo; Jiang, Lei; Klapars, Artis; Buchwald, Stephen L. Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6653 - 6655
N-Phenylanthranilic acid structure

N-Phenylanthran...

CAS#:91-40-7

~58%

SIRT-IN-3 Structure

SIRT-IN-3

CAS#:1211-19-4

Literature: Maruyama; Kawata; Ono; Nishizawa; Ito; Inoue Bioscience, biotechnology, and biochemistry, 2001 , vol. 65, # 8 p. 1761 - 1765
Benzoyl chloride, 2-(phenylamino)- structure

Benzoyl chlorid...

CAS#:57623-73-1

~%

SIRT-IN-3 Structure

SIRT-IN-3

CAS#:1211-19-4

Literature: ROCHE DIAGNOSTICS GMBH; F. HOFFMANN-LA ROCHE AG Patent: WO2008/52742 A1, 2008 ; Location in patent: Page/Page column 17; Sheet 1 ;
2-Anilinobenzoic acid methyl ester structure

2-Anilinobenzoi...

CAS#:35708-19-1

~%

SIRT-IN-3 Structure

SIRT-IN-3

CAS#:1211-19-4

Literature: Goodman; Arbiter; Powell Journal of the American Chemical Society, 1933 , vol. 55, p. 4294,4297, 4298
1-PHENYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE structure

1-PHENYL-1H-BEN...

CAS#:20877-86-5

~%

SIRT-IN-3 Structure

SIRT-IN-3

CAS#:1211-19-4

Literature: Coyne,W.E.; Cusic,J.W. Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1208 - 1213

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

N-phenyl-anthranilic acid amide
Benzamide,o-anilino
N-Phenyl-anthranilsaeure-amid
Anilinobenzamide
N-phenylanthranylamide
N-phenylanthranilamide
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Chemsrc provides SIRT-IN-3(CAS#:1211-19-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SIRT-IN-3 are included as well.>> amp version: SIRT-IN-3

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