UCN-02

Modify Date: 2024-01-25 00:05:17

UCN-02 Structure
UCN-02 structure
Common Name UCN-02
CAS Number 121569-61-7 Molecular Weight 482.537
Density N/A Boiling Point N/A
Molecular Formula C28H26N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of UCN-02


UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells[1][2].

 Names

Name ANTIBIOTIC UCN-02

 UCN-02 Biological Activity

Description UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor produced by Streptomyces strain N-12, with IC50s of 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively. UCN-02 (7-epi-Hydroxystaurosporine) displays cytotoxic effect on the growth of HeLa S3 cells[1][2].
Related Catalog
Target

IC50: 62 nM (PKC), 250 nM (PKA)[2]

References

[1]. Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation. J Antibiot (Tokyo). 1989 Apr;42(4):564-70.

[2]. Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo). 1989 Apr;42(4):571-6.

 Chemical & Physical Properties

Molecular Formula C28H26N4O4
Molecular Weight 482.537
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