Glucocorticoid receptor agonist
Modify Date: 2024-01-10 14:00:26
Glucocorticoid receptor agonist structure
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Common Name | Glucocorticoid receptor agonist | ||
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| CAS Number | 1245526-82-2 | Molecular Weight | 396.37900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H20F4N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Glucocorticoid receptor agonistGlucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist.IC50 value:Target: |
| Name | 4-fluoro-2-[(4R)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol |
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| Synonym | More Synonyms |
| Description | Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist.IC50 value:Target: |
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| Related Catalog | |
| Animal Admin | Animal administration [1]Female Balb/c mice weighing approximately 20 g were used. Mice were administered the test compound and in Cremophor (po) approximately 60 min prior to LPS/D-gal administration. The volume of oral gavage was 0.15 mL. Then mice were administered LPS (E. coli LPS 055:85, 1.0 μg/mouse) plus D-gal (50 mg/kg) intravenously in 0.2 mL of pyrogen-free saline. One hour after LPS/D-gal, each mouse was anesthetized, bled by cardiac puncture, and collected for serum TNF-R and compound levels. Blood samples were centrifuged at 2500 rpm for 10-15 min, the serum was decanted, and samples were stored frozen at -70°C until transfer either for TNF-R determination or to Drug Metabolism and Pharmacokinetics for plasma concentration analysis by HPLC. The concentration of TNF-R in the serum was measured by a commercially available ELISA kit. ELISA was performed. All samples are assayed in duplicate. |
| References |
| Molecular Formula | C20H20F4N2O2 |
|---|---|
| Molecular Weight | 396.37900 |
| Exact Mass | 396.14600 |
| PSA | 69.14000 |
| LogP | 4.61140 |
| Storage condition | 2-8℃ |
| Glucocorticoid receptor agonist |
| CS-0520 |