Glucocorticoid receptor-IN-1

Modify Date: 2024-01-09 16:42:36

Glucocorticoid receptor-IN-1 structure	Common Name	Glucocorticoid receptor-IN-1
	CAS Number	2662908-25-8	Molecular Weight	513.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₁₉F₄N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Glucocorticoid receptor-IN-1

Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC50 of 2.11 nM against hMMP1, and transcriptional activation activity with an EC50 of 5.59 nM against MMTV[1].

Name	Glucocorticoid receptor-IN-1

Description	Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC50 of 2.11 nM against hMMP1, and transcriptional activation activity with an EC50 of 5.59 nM against MMTV[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	Glucocorticoid receptor-IN-1 (Compound WX002) shows inhibitory effect on CYP3A4 with an IC50 of 16.7 µM[1].
References	[1]. Guoli Zhang, et al. Benzo[d][1,2,3]triazole ether compound. WO2021136431.

Molecular Formula	C₂₄H₁₉F₄N₇O₂
Molecular Weight	513.45

Glucocorticoid receptor-IN-1

Use of Glucocorticoid receptor-IN-1

Names

Glucocorticoid receptor-IN-1 Biological Activity

Chemical & Physical Properties