Rat CGRP-(8-37)

Modify Date: 2024-01-02 09:23:20

Rat CGRP-(8-37) structure	Common Name	Rat CGRP-(8-37)
	CAS Number	129121-73-9	Molecular Weight	3127.51000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃₈H₂₂₄N₄₂O₄₁	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Rat CGRP-(8-37)

Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.

Name	CGRP 8-37 (rat)
Synonym	More Synonyms

Description	Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CGRP Receptor Signaling Pathways >> Neuronal Signaling >> CGRP Receptor Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease Peptides
Target	CGRP receptor[1]
In Vitro	CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor[1].
In Vivo	CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses[1]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[2].
Animal Admin	Rats: Adult male Sprague Dawley rats are given a spinal hemisection or a sham surgery at the T13 spinal segment. An externally accessible PE-10 intrathecal catheter that terminated at T13 is used for drug delivery. Animals are allowed to recover for 4 weeks at which time the hemisected animals displayed mechanical and thermal allodynia bilaterally, in both forelimbs and hindlimbs. CGRP-(8-37) is delivered just prior to a testing session in 1, 5, 10, or 50 nM doses in artificial cerebral spinal fluid in 10 mL volumes[1].
References	[1]. Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75. [2]. Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30.

Molecular Formula	C₁₃₈H₂₂₄N₄₂O₄₁
Molecular Weight	3127.51000
Exact Mass	3125.67000
PSA	1344.65000
LogP	0.05010
Storage condition	-20°C

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Rat CGRP-(8-37)

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China
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Rat CGRP-(8-37)

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