Shanghai Nianxing Industrial Co., Ltd
China
Product Name: RatCGRP-(8-37)
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Nanjing Peptide Biotech Ltd
China
Product Name: α-CGRP (8-37) (mouse, rat)
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Taiwan Oyi peptide Co. Ltd
China
Product Name: Rat CGRP-(8-37)
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

129121-73-9

129121-73-9 structure

129121-73-9 structure

Name: Rat CGRP-(8-37)
Chemical Name: CGRP 8-37 (rat)
CAS Number: 129121-73-9
Molecular Formula: C₁₃₈H₂₂₄N₄₂O₄₁
Molecular Weight: 3127.51000
Catalog: Peptides
Create Date: 2018-06-16 17:27:21
Modify Date: 2024-01-02 09:23:20
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.

Name	CGRP 8-37 (rat)
Synonyms	h-val-thr-his-arg-leu-ala-gly-leu-leu-ser-arg-ser-gly-gly-val-val-lys-asp-asn-phe-val-pro-thr-asn-val-gly-ser-glu-ala-phe-nh2 val-thr-his-arg-leu-ala-gly-leu-leu-ser-arg-ser-gly-gly-val-val-lys-asp-asn-phe-val-pro-thr-asn-val-gly-ser-glu-ala-phe-nh2 vthrlagllsrsggvvkdnfvptnvgseaf-nh2 Rat CGRP-(8-37)

Description	Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CGRP Receptor Signaling Pathways >> Neuronal Signaling >> CGRP Receptor Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease Peptides
Target	CGRP receptor[1]
In Vitro	CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor[1].
In Vivo	CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses[1]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[2].
Animal Admin	Rats: Adult male Sprague Dawley rats are given a spinal hemisection or a sham surgery at the T13 spinal segment. An externally accessible PE-10 intrathecal catheter that terminated at T13 is used for drug delivery. Animals are allowed to recover for 4 weeks at which time the hemisected animals displayed mechanical and thermal allodynia bilaterally, in both forelimbs and hindlimbs. CGRP-(8-37) is delivered just prior to a testing session in 1, 5, 10, or 50 nM doses in artificial cerebral spinal fluid in 10 mL volumes[1].
References	[1]. Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75. [2]. Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30.

Molecular Formula	C₁₃₈H₂₂₄N₄₂O₄₁
Molecular Weight	3127.51000
Exact Mass	3125.67000
PSA	1344.65000
LogP	0.05010
Storage condition	-20°C