Biotin-PEG4-azide

Modify Date: 2024-01-05 21:05:34

Biotin-PEG4-azide Structure
Biotin-PEG4-azide structure
Common Name Biotin-PEG4-azide
CAS Number 1309649-57-7 Molecular Weight 488.601
Density N/A Boiling Point N/A
Molecular Formula C20H36N6O6S Melting Point 104 °C
MSDS N/A Flash Point N/A

 Use of Biotin-PEG4-azide


Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Biotin-PEG4-Azide
Synonym More Synonyms

 Biotin-PEG4-azide Biological Activity

Description Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

 Chemical & Physical Properties

Melting Point 104 °C
Molecular Formula C20H36N6O6S
Molecular Weight 488.601
Exact Mass 488.241699
LogP -1.28

 Synonyms

N-(14-Azido-3,6,9,12-tetraoxatetradec-1-yl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
MFCD27977501
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(14-azido-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-, (3aS,4S,6aR)-
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