UNC0631

Modify Date: 2024-01-02 17:19:11

UNC0631 Structure
UNC0631 structure
Common Name UNC0631
CAS Number 1320288-19-4 Molecular Weight 635.926
Density 1.1±0.1 g/cm3 Boiling Point 763.4±70.0 °C at 760 mmHg
Molecular Formula C37H61N7O2 Melting Point N/A
MSDS N/A Flash Point 415.5±35.7 °C

 Use of UNC0631


UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM.IC50 value: 4 nM [1]Target: G9aUNC 0631, which had high in vitro potency versus G9a and improved lipophilicity, was highly potent (IC50 < 0.06 μM) in reducing H3K9me2 levels in MDA-MB-231 cells and had low cell toxicity. In particular, compounds 7 was more potent than compound 5 and had a similar tox/function ratio in MDAMB-231 cells. UNC 0631 showed excellent separation of functional potency versus cell toxicity in MDA-MB-231 cells, thecompound was further evaluated in a variety of cell lines to characterize it's cellular potency and cell toxicity. UNC 0631 had excellent tox/functionratios in these cell lines.

 Names

Name N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-(4-isopropyl-1,4-diazepa n-1-yl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
Synonym More Synonyms

 UNC0631 Biological Activity

Description UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM.IC50 value: 4 nM [1]Target: G9aUNC 0631, which had high in vitro potency versus G9a and improved lipophilicity, was highly potent (IC50 < 0.06 μM) in reducing H3K9me2 levels in MDA-MB-231 cells and had low cell toxicity. In particular, compounds 7 was more potent than compound 5 and had a similar tox/function ratio in MDAMB-231 cells. UNC 0631 showed excellent separation of functional potency versus cell toxicity in MDA-MB-231 cells, thecompound was further evaluated in a variety of cell lines to characterize it's cellular potency and cell toxicity. UNC 0631 had excellent tox/functionratios in these cell lines.
Related Catalog
References

[1]. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 763.4±70.0 °C at 760 mmHg
Molecular Formula C37H61N7O2
Molecular Weight 635.926
Flash Point 415.5±35.7 °C
Exact Mass 635.488647
PSA 72.46000
LogP 6.29
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.579
Storage condition 2-8℃

 Synonyms

N-(1-(benzo[d][1,3]dioxol-5-yl)propyl)-4-methylbenzenesulfonamide
N-(1-(cyclohexylmethyl)piperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine
Benzenesulfonamide,N-[1-(1,3-benzodioxol-5-yl)propyl]-4-methyl
UNC0631
UNC 0631
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